tetano
Editor, Senior Moderator
Int J Clin Pract
. 2020 Sep 7;e13636.
doi: 10.1111/ijcp.13636. Online ahead of print.
Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients
Musab Ali Kutluhan[SUP] 1 [/SUP], Ahmet Taş[SUP] 1 [/SUP], Ayta? Şahin[SUP] 1 [/SUP], Ahmet ?rkmez[SUP] 1 [/SUP], Ramazan Topaktas[SUP] 2 [/SUP], ?mer Ata?[SUP] 3 [/SUP], Ayhan Verit[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease.
Objective: In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigated the effect of Covid-19 on kidney function.
Methods: Ninety-six patients diagnosed with Covid-19 were included in our study. Demographic features (Age, gender, co-morbidities), symptoms, thorax CT findings, Covid-19 PCR results and laboratory findings were recorded. The clinical features of the patients were analysed and kidney function values before Covid-19 diagnosis were compared with kidney function values after Covid-19 diagnosis.
Results: Most presenting symptom was fever (51%). Most accompanying co-morbidity was hypertension (56%). According to laboratory findings; ferritin, D-dimer and C-reactive protein levels were statistically significantly higher in ARDS group than severe pneumonia and pneumonia group (P = .002, P = .001 and P < .001, respectively). Also lymphocyte levels were statistically significantly lower in ARDS group than severe pneumonia and pneumonia group (P = .042). According to KDIGO criteria 3 (3.1%) patients had AKI during the hospital stay. For all patients, there was statistically significant difference between basal, 1st, 5th and 10th day BUN and SCr levels (P = .024 and P = .018, respectively). For severe pneumonia group there was statistically significant difference between basal, 1st, 5th and 10th day SCr levels (P = .045).
Conclusion: Our study demonstrated that Covid-19 can cause renal impairment both with pneumonia and ARDS. A large-scale prospective randomised studies are needed to reach final judgement about this topic.
. 2020 Sep 7;e13636.
doi: 10.1111/ijcp.13636. Online ahead of print.
Assessment of clinical features and renal functions in Coronavirus disease-19: A retrospective analysis of 96 patients
Musab Ali Kutluhan[SUP] 1 [/SUP], Ahmet Taş[SUP] 1 [/SUP], Ayta? Şahin[SUP] 1 [/SUP], Ahmet ?rkmez[SUP] 1 [/SUP], Ramazan Topaktas[SUP] 2 [/SUP], ?mer Ata?[SUP] 3 [/SUP], Ayhan Verit[SUP] 1 [/SUP]
Affiliations
- PMID: 32894811
- DOI: 10.1111/ijcp.13636
Abstract
Background: The most common extra pulmonary organ dysfunction in acute respiratory distress syndrome is acute kidney injury. Current data so far indicate low incidence of AKI in Covid-19 disease.
Objective: In this retrospective study, we analysed the clinical features of patients diagnosed with Covid-19 and investigated the effect of Covid-19 on kidney function.
Methods: Ninety-six patients diagnosed with Covid-19 were included in our study. Demographic features (Age, gender, co-morbidities), symptoms, thorax CT findings, Covid-19 PCR results and laboratory findings were recorded. The clinical features of the patients were analysed and kidney function values before Covid-19 diagnosis were compared with kidney function values after Covid-19 diagnosis.
Results: Most presenting symptom was fever (51%). Most accompanying co-morbidity was hypertension (56%). According to laboratory findings; ferritin, D-dimer and C-reactive protein levels were statistically significantly higher in ARDS group than severe pneumonia and pneumonia group (P = .002, P = .001 and P < .001, respectively). Also lymphocyte levels were statistically significantly lower in ARDS group than severe pneumonia and pneumonia group (P = .042). According to KDIGO criteria 3 (3.1%) patients had AKI during the hospital stay. For all patients, there was statistically significant difference between basal, 1st, 5th and 10th day BUN and SCr levels (P = .024 and P = .018, respectively). For severe pneumonia group there was statistically significant difference between basal, 1st, 5th and 10th day SCr levels (P = .045).
Conclusion: Our study demonstrated that Covid-19 can cause renal impairment both with pneumonia and ARDS. A large-scale prospective randomised studies are needed to reach final judgement about this topic.