tetano
Editor, Senior Moderator
Int J Clin Pract
. 2021 Sep 6;e14809.
doi: 10.1111/ijcp.14809. Online ahead of print.
Is there an association between urine biochemical parameters on admission and the severity of COVID-19?
Omer Erdogan[SUP] 1 [/SUP], Fesih Ok[SUP] 2 [/SUP], Serkan Carkci[SUP] 1 [/SUP], Emrullah Durmus[SUP] 1 [/SUP]
Affiliations
Abstract
Aim: To determine the importance of urinary biochemical parameters on the severity of coronavirus disease-2019 (COVID-19).
Methods: 133 patients who were diagnosed with COVID-19 were retrospectively included. Groups were formed according to the severity of their disease (moderate [n = 85], severe [n = 29], and critical = [n = 19]), and an additional control group was created from healthy individuals (n = 50). We investigated the correlation between urine biochemical parameters and the severity of the disease.
Results: Erythrocyturia, proteinuria, and glucosuria rates were significantly higher in patients than in the controls. In patients, the median urine specific gravity (SG) was lower (p < 0.001), and the median potential of hydrogen (pH) value was higher compared to the controls (p < 0.001). In correlation analyses, there were strong positive correlations between disease severity and age (r = 0.545, p < 0.001), RR (r = 0.838, p < 0.001), and proteinuria (r = 0.462, p < 0.001), while there was a strong negative correlation with SpO[SUB]2[/SUB] (r = -0.839, p = 0.001). On multivariate analysis, age (OR: 1.06, 95% CI 1.03-1.10, p=0.035), respiratory rate ≥30 breaths/ min (OR: 4.72, 95% CI 1.26-6.24, p<0.0031), SpO2 ≤93% (OR: 3.82, 95% CI 1.18-5.82, p=0.001) and proteinuria (OR: 1.13, 95%CI 1.02-2.1, p=0.023) were independent predictive factors for disease severity.
Conclusion: Proteinuria in routine urine analysis, which is one of the parameters that can be easily applied in the application, may be related to the severity of the COVID-19 disease.
Keywords: COVID-19; Urine biochemistry; coronavirus; severe disease.
. 2021 Sep 6;e14809.
doi: 10.1111/ijcp.14809. Online ahead of print.
Is there an association between urine biochemical parameters on admission and the severity of COVID-19?
Omer Erdogan[SUP] 1 [/SUP], Fesih Ok[SUP] 2 [/SUP], Serkan Carkci[SUP] 1 [/SUP], Emrullah Durmus[SUP] 1 [/SUP]
Affiliations
- PMID: 34487598
- DOI: 10.1111/ijcp.14809
Abstract
Aim: To determine the importance of urinary biochemical parameters on the severity of coronavirus disease-2019 (COVID-19).
Methods: 133 patients who were diagnosed with COVID-19 were retrospectively included. Groups were formed according to the severity of their disease (moderate [n = 85], severe [n = 29], and critical = [n = 19]), and an additional control group was created from healthy individuals (n = 50). We investigated the correlation between urine biochemical parameters and the severity of the disease.
Results: Erythrocyturia, proteinuria, and glucosuria rates were significantly higher in patients than in the controls. In patients, the median urine specific gravity (SG) was lower (p < 0.001), and the median potential of hydrogen (pH) value was higher compared to the controls (p < 0.001). In correlation analyses, there were strong positive correlations between disease severity and age (r = 0.545, p < 0.001), RR (r = 0.838, p < 0.001), and proteinuria (r = 0.462, p < 0.001), while there was a strong negative correlation with SpO[SUB]2[/SUB] (r = -0.839, p = 0.001). On multivariate analysis, age (OR: 1.06, 95% CI 1.03-1.10, p=0.035), respiratory rate ≥30 breaths/ min (OR: 4.72, 95% CI 1.26-6.24, p<0.0031), SpO2 ≤93% (OR: 3.82, 95% CI 1.18-5.82, p=0.001) and proteinuria (OR: 1.13, 95%CI 1.02-2.1, p=0.023) were independent predictive factors for disease severity.
Conclusion: Proteinuria in routine urine analysis, which is one of the parameters that can be easily applied in the application, may be related to the severity of the COVID-19 disease.
Keywords: COVID-19; Urine biochemistry; coronavirus; severe disease.