tetano
Editor, Senior Moderator
Int J Gynaecol Obstet
. 2021 Jun 29.
doi: 10.1002/ijgo.13804. Online ahead of print.
Mortality in pregnancy and the postpartum period in women with severe acute respiratory distress syndrome related to COVID-19 in Brazil, 2020
Carlos A Scheler[SUP] 1 [/SUP], Michelle G Discacciati[SUP] 1 [/SUP], Diama B Vale[SUP] 1 [/SUP], Giuliane J Lajos[SUP] 1 [/SUP], Fernanda de Castro Surita[SUP] 1 [/SUP], Julio C Teixeira[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: To estimate fatality rates due to severe acute respiratory distress syndrome (ARDS) related to COVID-19 in Brazilian women, comparing pregnant and postpartum women with nonpregnant women.
Methods: A cross-sectional study of 12 566 pregnant and postpartum women (obstetric group) and 90 025 nonpregnant women (nonobstetric group) aged 15-49 years reported with severe ARDS in 2020. The Brazilian ARDS Surveillance System was used to compare the outcome (death or cure) between the groups, considering age, race, or comorbidities.
Results: The mortality rate related to ARDS/COVID-19 in the obstetric group was 7.8% (377/4853) compared with 13.9% (5946/42 915) in the nonobstetric group. Comorbidity was associated with increased fatality cases for both groups, but higher in the nonobstetric group (22.8% vs 13.3%). In the obstetric group, deaths related to COVID-19 were concentrated in the third trimester or postpartum period. If comorbidity was present, deaths by COVID-19 were 4.4 times higher than ARDS due to other etiologies, and twice higher in women who self-reported as black (13.7%) than white women (6.7%). Considering ADRS etiology, deaths by COVID-19 were 3.4-6.7 times higher than any other etiology.
Conclusion: ARDS related to COVID-19 in obstetric patients was an important factor for worse clinical outcomes, with 3-6 times higher death rates than other ARDS etiologies. Pregnant and postpartum women with severe ARDS related to COVID-19 had a lower fatality rate than nonpregnant women, even with associated comorbidity.
Keywords: COVID-19; SARS-CoV-2; acute respiratory distress syndrome; case fatality; coronavirus; maternal death; maternal mortality; mortality rate; pregnancy.
. 2021 Jun 29.
doi: 10.1002/ijgo.13804. Online ahead of print.
Mortality in pregnancy and the postpartum period in women with severe acute respiratory distress syndrome related to COVID-19 in Brazil, 2020
Carlos A Scheler[SUP] 1 [/SUP], Michelle G Discacciati[SUP] 1 [/SUP], Diama B Vale[SUP] 1 [/SUP], Giuliane J Lajos[SUP] 1 [/SUP], Fernanda de Castro Surita[SUP] 1 [/SUP], Julio C Teixeira[SUP] 1 [/SUP]
Affiliations
- PMID: 34185314
- DOI: 10.1002/ijgo.13804
Abstract
Objective: To estimate fatality rates due to severe acute respiratory distress syndrome (ARDS) related to COVID-19 in Brazilian women, comparing pregnant and postpartum women with nonpregnant women.
Methods: A cross-sectional study of 12 566 pregnant and postpartum women (obstetric group) and 90 025 nonpregnant women (nonobstetric group) aged 15-49 years reported with severe ARDS in 2020. The Brazilian ARDS Surveillance System was used to compare the outcome (death or cure) between the groups, considering age, race, or comorbidities.
Results: The mortality rate related to ARDS/COVID-19 in the obstetric group was 7.8% (377/4853) compared with 13.9% (5946/42 915) in the nonobstetric group. Comorbidity was associated with increased fatality cases for both groups, but higher in the nonobstetric group (22.8% vs 13.3%). In the obstetric group, deaths related to COVID-19 were concentrated in the third trimester or postpartum period. If comorbidity was present, deaths by COVID-19 were 4.4 times higher than ARDS due to other etiologies, and twice higher in women who self-reported as black (13.7%) than white women (6.7%). Considering ADRS etiology, deaths by COVID-19 were 3.4-6.7 times higher than any other etiology.
Conclusion: ARDS related to COVID-19 in obstetric patients was an important factor for worse clinical outcomes, with 3-6 times higher death rates than other ARDS etiologies. Pregnant and postpartum women with severe ARDS related to COVID-19 had a lower fatality rate than nonpregnant women, even with associated comorbidity.
Keywords: COVID-19; SARS-CoV-2; acute respiratory distress syndrome; case fatality; coronavirus; maternal death; maternal mortality; mortality rate; pregnancy.