tetano
Editor, Senior Moderator
Int J Infect Dis
. 2024 Jul 19:107184.
doi: 10.1016/j.ijid.2024.107184. Online ahead of print. Vaccine-related influenza virus B infection in a child with an undiagnosed B-cell acute lymphoblastic leukemia
Giuseppe Di Pietra[SUP] 1 [/SUP], Sarah Di Sopra[SUP] 1 [/SUP], Valeria Conciatori[SUP] 1 [/SUP], Enrico Lavezzo[SUP] 1 [/SUP], Elisa Franchin[SUP] 2 [/SUP], Maria Grazia Petris[SUP] 3 [/SUP], Alessandra Biffi[SUP] 3 [/SUP], Ignazio Castagliuolo[SUP] 2 [/SUP], Cristiano Salata[SUP] 1 [/SUP], Claudia Del Vecchio[SUP] 4 [/SUP]
Affiliations
We report a case of Influenza type B (lineage Yamagata) infection in a child who received the live attenuated influenza virus vaccine before being diagnosed with B-cell acute lymphoblastic leukemia. The patient developed a mild disease that persisted for 18 days and resolved without antiviral treatment. The prolonged infection of an attenuated virus in an immunocompromised host might pose a risk of reversion or evolution to a more pathogenic strain. Prompt prevention, identification, and monitoring of similar cases are desirable to avoid the development of severe illness, which could complicate patient management.
Keywords: immunocompromised patient; influenza virus; leukemia; live vaccine.
. 2024 Jul 19:107184.
doi: 10.1016/j.ijid.2024.107184. Online ahead of print. Vaccine-related influenza virus B infection in a child with an undiagnosed B-cell acute lymphoblastic leukemia
Giuseppe Di Pietra[SUP] 1 [/SUP], Sarah Di Sopra[SUP] 1 [/SUP], Valeria Conciatori[SUP] 1 [/SUP], Enrico Lavezzo[SUP] 1 [/SUP], Elisa Franchin[SUP] 2 [/SUP], Maria Grazia Petris[SUP] 3 [/SUP], Alessandra Biffi[SUP] 3 [/SUP], Ignazio Castagliuolo[SUP] 2 [/SUP], Cristiano Salata[SUP] 1 [/SUP], Claudia Del Vecchio[SUP] 4 [/SUP]
Affiliations
- PMID: 39033799
- DOI: 10.1016/j.ijid.2024.107184
We report a case of Influenza type B (lineage Yamagata) infection in a child who received the live attenuated influenza virus vaccine before being diagnosed with B-cell acute lymphoblastic leukemia. The patient developed a mild disease that persisted for 18 days and resolved without antiviral treatment. The prolonged infection of an attenuated virus in an immunocompromised host might pose a risk of reversion or evolution to a more pathogenic strain. Prompt prevention, identification, and monitoring of similar cases are desirable to avoid the development of severe illness, which could complicate patient management.
Keywords: immunocompromised patient; influenza virus; leukemia; live vaccine.