tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Sep 16;S1201-9712(20)30745-1.
doi: 10.1016/j.ijid.2020.09.028. Online ahead of print.
Coronavirus Disease 2019 Population-based Prevalence, Risk Factors, Hospitalization, and Fatality Rates in Southern Brazil
Rafael V Picon[SUP] 1 [/SUP], Ion? Carreno[SUP] 2 [/SUP], Andr? Anjos da Silva[SUP] 3 [/SUP], M?rcio Mossmann[SUP] 4 [/SUP], Gabriela Laste[SUP] 5 [/SUP], Guilherme de Campos Domingues[SUP] 4 [/SUP], Lara Faria Fernandes Heringer[SUP] 4 [/SUP], Brenda Rodrigues Gheno[SUP] 4 [/SUP], Leticia Le?o Alvarenga[SUP] 4 [/SUP], Magali Conte[SUP] 6 [/SUP]
Affiliations
Abstract
Objectives: To assess population-based prevalence, risk factors, hospitalization, and infection fatality rates (IFR) associated with COVID-19.
Methods: We conducted two household surveys among the non-institutionalized adult population from May 30 to June 17, 2020, in Lajeado, an 84,000-inhabitants industrial city in southern Brazil. Primary outcome was prevalence of SARS-CoV-2 infection. Secondary outcomes were COVID-19 hospitalizations and deaths occurring up to June 20, 2020. We summarized prevalence rates across surveys with meta-analysis. We assessed age-range IFR and hospitalization rate and regressed these rates over age strata using nonlinear coefficients of determination (R[SUP]2[/SUP]).
Results: Summarized overall prevalence was 3.40% (95% CI, 2.74 to 4.18), 34% lower in elderly ≥60 years-old. IFR ranged from 0.08% (0.06 to 0.11) to 4.63% (2.93 to 7.84) in individuals 20 to 39 years-old and ≥60 years-old, respectively. R[SUP]2[/SUP] for exponential age-dependent hospitalization rate and IFR were 0.98 and 0.93 (both p-values <0.0001), respectively.
Conclusions: This is the first population-based study in Brazil to estimate COVID-19 prevalence, hospitalization and fatality rates per age stratum. Rates were largely age-dependent. Household contacts and MPP workers are at higher risk of infection. Our findings are valuable for health-policy making and resource allocation to mitigate the pandemic.
Keywords: COVID-19; SARS-CoV-2; hospitalization; infection fatality rate; prevalence.
. 2020 Sep 16;S1201-9712(20)30745-1.
doi: 10.1016/j.ijid.2020.09.028. Online ahead of print.
Coronavirus Disease 2019 Population-based Prevalence, Risk Factors, Hospitalization, and Fatality Rates in Southern Brazil
Rafael V Picon[SUP] 1 [/SUP], Ion? Carreno[SUP] 2 [/SUP], Andr? Anjos da Silva[SUP] 3 [/SUP], M?rcio Mossmann[SUP] 4 [/SUP], Gabriela Laste[SUP] 5 [/SUP], Guilherme de Campos Domingues[SUP] 4 [/SUP], Lara Faria Fernandes Heringer[SUP] 4 [/SUP], Brenda Rodrigues Gheno[SUP] 4 [/SUP], Leticia Le?o Alvarenga[SUP] 4 [/SUP], Magali Conte[SUP] 6 [/SUP]
Affiliations
- PMID: 32949778
- DOI: 10.1016/j.ijid.2020.09.028
Abstract
Objectives: To assess population-based prevalence, risk factors, hospitalization, and infection fatality rates (IFR) associated with COVID-19.
Methods: We conducted two household surveys among the non-institutionalized adult population from May 30 to June 17, 2020, in Lajeado, an 84,000-inhabitants industrial city in southern Brazil. Primary outcome was prevalence of SARS-CoV-2 infection. Secondary outcomes were COVID-19 hospitalizations and deaths occurring up to June 20, 2020. We summarized prevalence rates across surveys with meta-analysis. We assessed age-range IFR and hospitalization rate and regressed these rates over age strata using nonlinear coefficients of determination (R[SUP]2[/SUP]).
Results: Summarized overall prevalence was 3.40% (95% CI, 2.74 to 4.18), 34% lower in elderly ≥60 years-old. IFR ranged from 0.08% (0.06 to 0.11) to 4.63% (2.93 to 7.84) in individuals 20 to 39 years-old and ≥60 years-old, respectively. R[SUP]2[/SUP] for exponential age-dependent hospitalization rate and IFR were 0.98 and 0.93 (both p-values <0.0001), respectively.
Conclusions: This is the first population-based study in Brazil to estimate COVID-19 prevalence, hospitalization and fatality rates per age stratum. Rates were largely age-dependent. Household contacts and MPP workers are at higher risk of infection. Our findings are valuable for health-policy making and resource allocation to mitigate the pandemic.
Keywords: COVID-19; SARS-CoV-2; hospitalization; infection fatality rate; prevalence.