tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 May 19;S1201-9712(21)00434-3.
doi: 10.1016/j.ijid.2021.05.032. Online ahead of print.
Day by day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalised health-care workers: a 90-day follow-up study
Kent J Nielsen[SUP] 1 [/SUP], Jesper Medom Vestergaard[SUP] 2 [/SUP], Vivi Schl?nssen[SUP] 3 [/SUP], Jens Peter Bonde[SUP] 4 [/SUP], Kathrine Agerg?rd Kaspersen[SUP] 5 [/SUP], Karin Biering[SUP] 1 [/SUP], Ole Carstensen[SUP] 1 [/SUP], Thomas Greve[SUP] 6 [/SUP], Karoline K?rgaard Hansen[SUP] 2 [/SUP], Annett Dalb?ge[SUP] 2 [/SUP], Esben Meulengracht Flachs[SUP] 4 [/SUP], Sanne Jespersen[SUP] 7 [/SUP], Mette Lausten Hansen[SUP] 2 [/SUP], Susan Mikkelsen[SUP] 8 [/SUP], Marianne Kragh Thomsen[SUP] 6 [/SUP], Jacob Dvinge Redder[SUP] 9 [/SUP], Else Toft W?rtz[SUP] 2 [/SUP], Lars ?stergaard[SUP] 7 [/SUP], Christian Erikstrup[SUP] 8 [/SUP], Henrik Albert Kolstad[SUP] 10 [/SUP]
Affiliations
Abstract
Objective: We aimed to compare symptoms day by day for non-hospitalised individuals tested positive and negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: We followed 210 test-positive and 630 test-negative health-care workers of the Central Denmark Region up to 90 days after the test, April-June 2020. They daily reported COVID-19 related symptoms that were compared graphically and by logistic regression.
Results: Thirty % of test-positive and close to zero of test-negative participants reported reduced sense of taste and smell during all 90 days (adjusted odds ratio [aOR] 86.07, 95% CI 22.86-323). Dyspnoea was reported by an initial 20% of test-positive declining to 5% after 30 days without ever reaching the level of the test-negative participants (aOR 6.88, 95% CI 2.41-19.63). Cough, headache, sore throat, muscle pain, and fever were temporarily more prevalent among the test positive participants; after 30 days, no increases were seen. Women and older participants were more susceptible to COVID-19 symptoms.
Conclusion: Prevalence of long-lasting reduced sense of taste and smell is highly increased in mild COVID-19 patients. This pattern is also seen for dyspnoea at a low level but not for cough, sore throat, headache, muscle pain, or fever.
Keywords: Ageusia; Anosmia; Dyspnoea; Long-haul COVID-19; Post-COVID-19; Post-acute COVID-19 syndrome.
. 2021 May 19;S1201-9712(21)00434-3.
doi: 10.1016/j.ijid.2021.05.032. Online ahead of print.
Day by day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalised health-care workers: a 90-day follow-up study
Kent J Nielsen[SUP] 1 [/SUP], Jesper Medom Vestergaard[SUP] 2 [/SUP], Vivi Schl?nssen[SUP] 3 [/SUP], Jens Peter Bonde[SUP] 4 [/SUP], Kathrine Agerg?rd Kaspersen[SUP] 5 [/SUP], Karin Biering[SUP] 1 [/SUP], Ole Carstensen[SUP] 1 [/SUP], Thomas Greve[SUP] 6 [/SUP], Karoline K?rgaard Hansen[SUP] 2 [/SUP], Annett Dalb?ge[SUP] 2 [/SUP], Esben Meulengracht Flachs[SUP] 4 [/SUP], Sanne Jespersen[SUP] 7 [/SUP], Mette Lausten Hansen[SUP] 2 [/SUP], Susan Mikkelsen[SUP] 8 [/SUP], Marianne Kragh Thomsen[SUP] 6 [/SUP], Jacob Dvinge Redder[SUP] 9 [/SUP], Else Toft W?rtz[SUP] 2 [/SUP], Lars ?stergaard[SUP] 7 [/SUP], Christian Erikstrup[SUP] 8 [/SUP], Henrik Albert Kolstad[SUP] 10 [/SUP]
Affiliations
- PMID: 34022336
- DOI: 10.1016/j.ijid.2021.05.032
Abstract
Objective: We aimed to compare symptoms day by day for non-hospitalised individuals tested positive and negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: We followed 210 test-positive and 630 test-negative health-care workers of the Central Denmark Region up to 90 days after the test, April-June 2020. They daily reported COVID-19 related symptoms that were compared graphically and by logistic regression.
Results: Thirty % of test-positive and close to zero of test-negative participants reported reduced sense of taste and smell during all 90 days (adjusted odds ratio [aOR] 86.07, 95% CI 22.86-323). Dyspnoea was reported by an initial 20% of test-positive declining to 5% after 30 days without ever reaching the level of the test-negative participants (aOR 6.88, 95% CI 2.41-19.63). Cough, headache, sore throat, muscle pain, and fever were temporarily more prevalent among the test positive participants; after 30 days, no increases were seen. Women and older participants were more susceptible to COVID-19 symptoms.
Conclusion: Prevalence of long-lasting reduced sense of taste and smell is highly increased in mild COVID-19 patients. This pattern is also seen for dyspnoea at a low level but not for cough, sore throat, headache, muscle pain, or fever.
Keywords: Ageusia; Anosmia; Dyspnoea; Long-haul COVID-19; Post-COVID-19; Post-acute COVID-19 syndrome.