tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 May 30;S1201-9712(22)00323-X.
doi: 10.1016/j.ijid.2022.05.059. Online ahead of print.
Effectiveness of influenza vaccination on in-hospital death and recurrent hospitalization in older adults with cardiovascular diseases
Yuanjie Pang[SUP] 1 [/SUP], Xiaofan Liu[SUP] 2 [/SUP], Guangqi Liu[SUP] 3 [/SUP], Min Lv[SUP] 4 [/SUP], Ming Lu[SUP] 5 [/SUP], Jiang Wu[SUP] 4 [/SUP], Yangmu Huang[SUP] 6 [/SUP]
Affiliations
Abstract
Background: There is limited evidence on the effectiveness of influenza vaccination on hospitalization outcomes by cardiovascular diseases (CVDs) subtypes or comorbidities.
Methods: This study involved 713,488 records of hospitalization of adults ≥60 years with CVD from the Beijing Urban Employee Basic Medical Insurance database. Logistic regression with generalized estimating equations was conducted to estimate the effectiveness of influenza vaccination on in-hospital death and recurrent hospitalization adjusting for unmeasured confounders.
Results: The coverage of influenza vaccination was only 13.3% among older adults hospitalized for CVD. Influenza vaccination was associated with 15% (odds ratios 0.85 [0.74, 0.99]) lower risk of in-hospital death among CVD patients, with stronger associations in stroke patients. Influenza vaccination was associated with 6% (0.94 [0.88, 0.99]) and 28% (0.72 [0.56, 0.93]) lower risks of recurrent hospitalization for ischemic heart disease (IHD) and respiratory disease in IHD patients, but there were no clear associations in stroke patients. For in-hospital death, the protective association of influenza vaccination was stronger in patients with fewer comorbidities and was similar to that of joint vaccinations of influenza and pneumococcal vaccinations.
Conclusions: The protective effect of influenza vaccination on CVD hospitalization outcomes serves as the evidence base to increase the uptake of influenza vaccination among older adults in China.
Keywords: Influenza vaccination; cardiovascular diseases; in-hospital death; older adults; recurrent hospitalization.
. 2022 May 30;S1201-9712(22)00323-X.
doi: 10.1016/j.ijid.2022.05.059. Online ahead of print.
Effectiveness of influenza vaccination on in-hospital death and recurrent hospitalization in older adults with cardiovascular diseases
Yuanjie Pang[SUP] 1 [/SUP], Xiaofan Liu[SUP] 2 [/SUP], Guangqi Liu[SUP] 3 [/SUP], Min Lv[SUP] 4 [/SUP], Ming Lu[SUP] 5 [/SUP], Jiang Wu[SUP] 4 [/SUP], Yangmu Huang[SUP] 6 [/SUP]
Affiliations
- PMID: 35654282
- DOI: 10.1016/j.ijid.2022.05.059
Abstract
Background: There is limited evidence on the effectiveness of influenza vaccination on hospitalization outcomes by cardiovascular diseases (CVDs) subtypes or comorbidities.
Methods: This study involved 713,488 records of hospitalization of adults ≥60 years with CVD from the Beijing Urban Employee Basic Medical Insurance database. Logistic regression with generalized estimating equations was conducted to estimate the effectiveness of influenza vaccination on in-hospital death and recurrent hospitalization adjusting for unmeasured confounders.
Results: The coverage of influenza vaccination was only 13.3% among older adults hospitalized for CVD. Influenza vaccination was associated with 15% (odds ratios 0.85 [0.74, 0.99]) lower risk of in-hospital death among CVD patients, with stronger associations in stroke patients. Influenza vaccination was associated with 6% (0.94 [0.88, 0.99]) and 28% (0.72 [0.56, 0.93]) lower risks of recurrent hospitalization for ischemic heart disease (IHD) and respiratory disease in IHD patients, but there were no clear associations in stroke patients. For in-hospital death, the protective association of influenza vaccination was stronger in patients with fewer comorbidities and was similar to that of joint vaccinations of influenza and pneumococcal vaccinations.
Conclusions: The protective effect of influenza vaccination on CVD hospitalization outcomes serves as the evidence base to increase the uptake of influenza vaccination among older adults in China.
Keywords: Influenza vaccination; cardiovascular diseases; in-hospital death; older adults; recurrent hospitalization.