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Int J Infect Dis . Erythema nodosum as an unusual skin manifestation of long COVID: A case report

tetano

Editor, Senior Moderator
Int J Infect Dis


. 2024 Jun 25:107152.
doi: 10.1016/j.ijid.2024.107152. Online ahead of print. Erythema nodosum as an unusual skin manifestation of long COVID: A case report

Yu Jung Choi[SUP] 1 [/SUP], Han-Na Kim[SUP] 2 [/SUP], Jiyeon Lee[SUP] 3 [/SUP], Eliel Nham[SUP] 1 [/SUP], Hye Seong[SUP] 1 [/SUP], Jin Gu Yoon[SUP] 1 [/SUP], Ji Yun Noh[SUP] 1 [/SUP], Joon Young Song[SUP] 1 [/SUP], Hee Jin Cheong[SUP] 1 [/SUP], Woo Joo Kim[SUP] 4 [/SUP]



Affiliations
Abstract

Erythema nodosum (EN) is a skin manifestation of panniculitis characterized by symmetric, painful, tender nodules, and most cases are self-limiting. Few cases of EN following Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination have been reported, and they are generally self-limiting. We reported the challenging case of a 63-year-old Asian woman with EN that persisted for more than three months after a coronavirus disease-19 (COVID-19). There was no improvement despite topical steroid and NSAIDs treatment, and the patient was successfully treated with combination of high-dose steroid and NSAIDs. There were long-lasting symptoms involving various organ symptoms persisting over three months after COVID-19, which is known as Long COVID. As part of Long COVID, there are limited cases of skin manifestations. Given that immune dysregulation due to persistent coronaviruses may contribute to refractory EN, Erythema nodosum related to COVID-19 is rare, but can occur; clinicians should be aware of the occurrence of EN following COVID-19 infection.


 
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