tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Mar 5;S1201-9712(21)00210-1.
doi: 10.1016/j.ijid.2021.03.005. Online ahead of print.
Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
Paolo Calistri[SUP] 1 [/SUP], Laura Amato[SUP] 2 [/SUP], Ilaria Puglia[SUP] 2 [/SUP], Francesca Cito[SUP] 2 [/SUP], Alessandra Di Giuseppe[SUP] 2 [/SUP], Maria Luisa Danzetta[SUP] 2 [/SUP], Daniela Morelli[SUP] 2 [/SUP], Marco Di Domenico[SUP] 2 [/SUP], Marialuigia Caporale[SUP] 2 [/SUP], Silvia Scialabba[SUP] 2 [/SUP], Ottavio Portanti[SUP] 2 [/SUP], Valentina Curini[SUP] 2 [/SUP], Fabrizia Perletta[SUP] 2 [/SUP], Cesare Camm?[SUP] 2 [/SUP], Massimo Ancora[SUP] 2 [/SUP], Giovanni Savini[SUP] 2 [/SUP], Giacomo Migliorati[SUP] 2 [/SUP], Nicola D'Alterio[SUP] 2 [/SUP], Alessio Lorusso[SUP] 2 [/SUP]
Affiliations
Abstract
Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom a targeted surveillance was put in place in Abruzzo region (Italy), which allowed to detect 313 persons affected by lineage B.1.1.7, up to the 20[SUP]th[/SUP] of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021, to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of C[SUB]T[/SUB] associated with the detection of the N protein encoding gene (C[SUB]T[/SUB] N) were observed in persons with lineage B.1.1.7 infection (median C[SUB]T[/SUB] N = 15.8) in comparison to those infected by other lineages (median C[SUB]T[/SUB] N = 16.9). A significant longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).
Keywords: Abruzzo; Italy; SARS-CoV-2; VOC 202012/01; coronavirus; lineage B.1.1.7.
. 2021 Mar 5;S1201-9712(21)00210-1.
doi: 10.1016/j.ijid.2021.03.005. Online ahead of print.
Infection sustained by lineage B.1.1.7 of SARS-CoV-2 is characterised by longer persistence and higher viral RNA loads in nasopharyngeal swabs
Paolo Calistri[SUP] 1 [/SUP], Laura Amato[SUP] 2 [/SUP], Ilaria Puglia[SUP] 2 [/SUP], Francesca Cito[SUP] 2 [/SUP], Alessandra Di Giuseppe[SUP] 2 [/SUP], Maria Luisa Danzetta[SUP] 2 [/SUP], Daniela Morelli[SUP] 2 [/SUP], Marco Di Domenico[SUP] 2 [/SUP], Marialuigia Caporale[SUP] 2 [/SUP], Silvia Scialabba[SUP] 2 [/SUP], Ottavio Portanti[SUP] 2 [/SUP], Valentina Curini[SUP] 2 [/SUP], Fabrizia Perletta[SUP] 2 [/SUP], Cesare Camm?[SUP] 2 [/SUP], Massimo Ancora[SUP] 2 [/SUP], Giovanni Savini[SUP] 2 [/SUP], Giacomo Migliorati[SUP] 2 [/SUP], Nicola D'Alterio[SUP] 2 [/SUP], Alessio Lorusso[SUP] 2 [/SUP]
Affiliations
- PMID: 33684558
- DOI: 10.1016/j.ijid.2021.03.005
Abstract
Following the announcement on December 2020 about the emergence of a new variant (VOC 202012/01, B.1.1.7 lineage) in the United Kingdom a targeted surveillance was put in place in Abruzzo region (Italy), which allowed to detect 313 persons affected by lineage B.1.1.7, up to the 20[SUP]th[/SUP] of February 2021. We investigated the results of RT-PCR on nasopharyngeal swabs tested from December 2020 to February 2021, to verify any difference on the viral load and persistence between people infected by lineage B.1.1.7 and others. Statistically significant lower values of C[SUB]T[/SUB] associated with the detection of the N protein encoding gene (C[SUB]T[/SUB] N) were observed in persons with lineage B.1.1.7 infection (median C[SUB]T[/SUB] N = 15.8) in comparison to those infected by other lineages (median C[SUB]T[/SUB] N = 16.9). A significant longer duration of the persistence of SARS-CoV-2 RNA in nasopharyngeal swabs was observed in persons with lineage B.1.1.7 infection (16 days) in comparison to those infected by other lineages (14 days).
Keywords: Abruzzo; Italy; SARS-CoV-2; VOC 202012/01; coronavirus; lineage B.1.1.7.