tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Jun 14;S1201-9712(20)30470-7.
doi: 10.1016/j.ijid.2020.06.035. Online ahead of print.
Inoculum at the Time of SARS-CoV-2 Exposure and Risk of Disease Severity
Mar?a Pilar Guallar[SUP] 1 [/SUP], Rosa Meiri?o[SUP] 2 [/SUP], Carolina Donat-Vargas[SUP] 3 [/SUP], Octavio Corral[SUP] 4 [/SUP], Nicol?s Jouv?[SUP] 5 [/SUP], Vicente Soriano[SUP] 6 [/SUP]
Affiliations
Abstract
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were exposed to diverse inoculi in Madrid and overall developed divrgent clinical forms of COVID-19. Our data support that a greater SARS-CoV-2 inoculi at the time of exposure might determine a higher risk of severe COVID-19.
Keywords: COVID-19; Coronavirus; Disease severity; Epidemiology; Inoculum; Outbreak; Transmission.
. 2020 Jun 14;S1201-9712(20)30470-7.
doi: 10.1016/j.ijid.2020.06.035. Online ahead of print.
Inoculum at the Time of SARS-CoV-2 Exposure and Risk of Disease Severity
Mar?a Pilar Guallar[SUP] 1 [/SUP], Rosa Meiri?o[SUP] 2 [/SUP], Carolina Donat-Vargas[SUP] 3 [/SUP], Octavio Corral[SUP] 4 [/SUP], Nicol?s Jouv?[SUP] 5 [/SUP], Vicente Soriano[SUP] 6 [/SUP]
Affiliations
- PMID: 32553720
- DOI: 10.1016/j.ijid.2020.06.035
Abstract
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were exposed to diverse inoculi in Madrid and overall developed divrgent clinical forms of COVID-19. Our data support that a greater SARS-CoV-2 inoculi at the time of exposure might determine a higher risk of severe COVID-19.
Keywords: COVID-19; Coronavirus; Disease severity; Epidemiology; Inoculum; Outbreak; Transmission.