tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Aug 9;S1201-9712(21)00647-0.
doi: 10.1016/j.ijid.2021.08.015. Online ahead of print.
SARS-CoV-2 is localized in cardiomyocytes: a post-mortem biopsy case
Yoshihiko Nakamura[SUP] 1 [/SUP], Harutaka Katano[SUP] 2 [/SUP], Noriko Nakajima[SUP] 3 [/SUP], Yuko Sato[SUP] 4 [/SUP], Tadaki Suzuki[SUP] 5 [/SUP], Tsuyoshi Sekizuka[SUP] 6 [/SUP], Makoto Kuroda[SUP] 7 [/SUP], Yoshito Izutani[SUP] 8 [/SUP], Shinichi Morimoto[SUP] 9 [/SUP], Junichi Maruyama[SUP] 10 [/SUP], Megumi Koie[SUP] 11 [/SUP], Taisuke Kitamura[SUP] 12 [/SUP], Hiroyasu Ishikura[SUP] 13 [/SUP]
Affiliations
Abstract
A 72-year-old patient was admitted to the ICU due to acute respiratory distress syndrome caused by coronavirus disease 2019. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3-V6 and severe left ventricular dysfunction with an ejection fraction of 35%-40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyze the direct link between SARS-CoV2 and cardiomyocytes.
Keywords: SARS-CoV-2; cardiomyocyte; co-localization; immunostaining.
. 2021 Aug 9;S1201-9712(21)00647-0.
doi: 10.1016/j.ijid.2021.08.015. Online ahead of print.
SARS-CoV-2 is localized in cardiomyocytes: a post-mortem biopsy case
Yoshihiko Nakamura[SUP] 1 [/SUP], Harutaka Katano[SUP] 2 [/SUP], Noriko Nakajima[SUP] 3 [/SUP], Yuko Sato[SUP] 4 [/SUP], Tadaki Suzuki[SUP] 5 [/SUP], Tsuyoshi Sekizuka[SUP] 6 [/SUP], Makoto Kuroda[SUP] 7 [/SUP], Yoshito Izutani[SUP] 8 [/SUP], Shinichi Morimoto[SUP] 9 [/SUP], Junichi Maruyama[SUP] 10 [/SUP], Megumi Koie[SUP] 11 [/SUP], Taisuke Kitamura[SUP] 12 [/SUP], Hiroyasu Ishikura[SUP] 13 [/SUP]
Affiliations
- PMID: 34384897
- DOI: 10.1016/j.ijid.2021.08.015
Abstract
A 72-year-old patient was admitted to the ICU due to acute respiratory distress syndrome caused by coronavirus disease 2019. On day 20, the patient experienced shock. The electrocardiogram showed ST segment elevation in leads V3-V6 and severe left ventricular dysfunction with an ejection fraction of 35%-40%. The left ventricle showed basal hypokinesis and apical akinesis, while the creatine kinase level was normal, indicating Takotsubo cardiomyopathy. On day 24, the patient died of multiple organ failure. In post-mortem biopsy, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen was detected in cardiomyocytes by immunostaining. Moreover, SARS-CoV-2 RNA was detected in heart tissue. We need to further analyze the direct link between SARS-CoV2 and cardiomyocytes.
Keywords: SARS-CoV-2; cardiomyocyte; co-localization; immunostaining.