tetano
Editor, Senior Moderator
Int J Infect Dis
. 2020 Sep 25;S1201-9712(20)32152-4.
doi: 10.1016/j.ijid.2020.09.1436. Online ahead of print.
SARS-COV2 infection in 30 HIV-infected patients followed-up in a French University Hospital
Valentina Isernia[SUP] 1 [/SUP], Zelie Julia[SUP] 2 [/SUP], Sylvie Le Gac[SUP] 2 [/SUP], Antoine Bachelard[SUP] 3 [/SUP], Roland Landman[SUP] 3 [/SUP], Sylvie Lariven[SUP] 3 [/SUP], V?ronique Joly[SUP] 3 [/SUP], Laur?ne Deconinck[SUP] 3 [/SUP], Christophe Rioux[SUP] 3 [/SUP], Xavier Lescure[SUP] 4 [/SUP], Yazdan Yazdanpanah[SUP] 4 [/SUP], Jade Ghosn[SUP] 4 [/SUP]
Affiliations
Abstract
Introduction: An acute respiratory disease caused by a novel coronavirus (SARSCOV2) is spreading from China since January 2020. Surprisingly, few cases of Covid- 19 have been reported in people living with HIV (PLWHIV).
Methods: Here we present a series of 30 PLWHIV diagnosed for SARS-COV2 infection. The principal outcome was to describe clinical characteristics of this population.
Results: Eighteen (60%) patients were men, 10/30 (33,3%) women and 2/30 (6,7%) transgender women. Median age was 53,7 years (range 30-80 years) and 23/30 patients (76,7%) were born in a foreign country (out of France). The most common comorbidities were cardiovascular disease (11/30, 36,7%), hypertension (11/30, 36,7%), diabetes (9/30,30%) obesity (7/30, 23%) and chronic renal disease (5/30, 16,7%). Twenty (66,7%) patients presented overweight. Five patients (16,7%) had a Charlson comorbidity [1] score ≥3. Twenty-seven (90%) patients were virologically suppressed.CD4 count was >500 cell/mm 3 in 23/30 (76,6%) patients. An antiviral treatment for SARS-COV2 was administered, in addition to HIV treatment, in 5/30 patients (16,3%). Twenty-four patients (80%) recovered from covid-19, 3/30 (10%) required invasive mechanical ventilation, 2/30 (6,7%) patients died and 4/30 (13,3%) patients were still hospitalized.
Conclusions: Most of the patients were virologically suppressed with CD4 > 500 mm3. Risk factors were the same as those described in other SARS-COV2 series, suggesting that HIV infection is probably not an independent risk factor for covid-19.
Keywords: PLWHIV; SARS-COV2; SARS-COV2 risk-factors; pandemic.
. 2020 Sep 25;S1201-9712(20)32152-4.
doi: 10.1016/j.ijid.2020.09.1436. Online ahead of print.
SARS-COV2 infection in 30 HIV-infected patients followed-up in a French University Hospital
Valentina Isernia[SUP] 1 [/SUP], Zelie Julia[SUP] 2 [/SUP], Sylvie Le Gac[SUP] 2 [/SUP], Antoine Bachelard[SUP] 3 [/SUP], Roland Landman[SUP] 3 [/SUP], Sylvie Lariven[SUP] 3 [/SUP], V?ronique Joly[SUP] 3 [/SUP], Laur?ne Deconinck[SUP] 3 [/SUP], Christophe Rioux[SUP] 3 [/SUP], Xavier Lescure[SUP] 4 [/SUP], Yazdan Yazdanpanah[SUP] 4 [/SUP], Jade Ghosn[SUP] 4 [/SUP]
Affiliations
- PMID: 32987182
- PMCID: PMC7518976
- DOI: 10.1016/j.ijid.2020.09.1436
Abstract
Introduction: An acute respiratory disease caused by a novel coronavirus (SARSCOV2) is spreading from China since January 2020. Surprisingly, few cases of Covid- 19 have been reported in people living with HIV (PLWHIV).
Methods: Here we present a series of 30 PLWHIV diagnosed for SARS-COV2 infection. The principal outcome was to describe clinical characteristics of this population.
Results: Eighteen (60%) patients were men, 10/30 (33,3%) women and 2/30 (6,7%) transgender women. Median age was 53,7 years (range 30-80 years) and 23/30 patients (76,7%) were born in a foreign country (out of France). The most common comorbidities were cardiovascular disease (11/30, 36,7%), hypertension (11/30, 36,7%), diabetes (9/30,30%) obesity (7/30, 23%) and chronic renal disease (5/30, 16,7%). Twenty (66,7%) patients presented overweight. Five patients (16,7%) had a Charlson comorbidity [1] score ≥3. Twenty-seven (90%) patients were virologically suppressed.CD4 count was >500 cell/mm 3 in 23/30 (76,6%) patients. An antiviral treatment for SARS-COV2 was administered, in addition to HIV treatment, in 5/30 patients (16,3%). Twenty-four patients (80%) recovered from covid-19, 3/30 (10%) required invasive mechanical ventilation, 2/30 (6,7%) patients died and 4/30 (13,3%) patients were still hospitalized.
Conclusions: Most of the patients were virologically suppressed with CD4 > 500 mm3. Risk factors were the same as those described in other SARS-COV2 series, suggesting that HIV infection is probably not an independent risk factor for covid-19.
Keywords: PLWHIV; SARS-COV2; SARS-COV2 risk-factors; pandemic.