tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Aug 16;S1201-9712(21)00661-5.
doi: 10.1016/j.ijid.2021.08.028. Online ahead of print.
Seroprevalence and risk factors for SARS-CoV-2 Infection in selected urban areas in Ethiopia: a cross-sectional evaluation during July 2020
Enyew Birru Tadesse[SUP] 1 [/SUP], Abduilhafiz A Endris[SUP] 2 [/SUP], Henok Solomon[SUP] 2 [/SUP], Mikias Alayu[SUP] 2 [/SUP], Adisu Kebede[SUP] 2 [/SUP], Kirubel Eshetu[SUP] 2 [/SUP], Gizaw Teka[SUP] 2 [/SUP], Biniyam Eskinder Seid[SUP] 3 [/SUP], Jelaludin Ahmed[SUP] 3 [/SUP], Sisay Alemayehu Abayneh[SUP] 3 [/SUP], Beyene Mogesc Hizikiyas Gerawork[SUP] 4 [/SUP], David Sugerman[SUP] 3 [/SUP], Zewdu Assefa[SUP] 2 [/SUP], Aschalew Abayneh[SUP] 2 [/SUP], Ebba Abate[SUP] 2 [/SUP], Lia Taddese[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Ethiopia reported the first case of COVID-19 on March 13[SUP]th[/SUP], 2020 with community transmission ensue by mid-May. National, population-based serosurvey against anti-SARS-CoV-2 IgG was conducted to measure the prevalence of prior COVID-19 infections and better approximate the burden across major towns in Ethiopia.
Methods: We conducted a cross-sectional, population-based serosurvey from June 24 to July 8, 2020 in 14 major urban areas. Two-stage cluster sampling was used to randomly select enumeration areas and households. All persons aged ≥15 years were enrolled. Serum samples tested by Abbott™ ARCHITECT™ assay for SARS-CoV-2 IgG antibodies. National COVID-19 surveillance data on the median date of the serosurvey is analyzed for comparison.
Findings: Adjusted seroprevalence was 3.5% (95% CI: 3.2%-3.8%) after controlling for age, sex and test kit performance. Males (3.7%) and females (3.3%) were nearly equally infected, while middle-aged adults 40-65 years had the highest (4.0%) prevalence. Gambella (7.5%), Dire Dawa (6.2%) and Jigjiga (6.1%) were most affected towns. About 6.7% and 8.0% of seropositives had symptoms and chronic underlying illness, respectively. Surveillance system had identified 4,416 RT-PCR confirmed cases in Addis Ababa.
Interpretation: This serosurvey shows majority of urban Ethiopians remain uninfected with SARS-CoV-2. Most anti-SARS-CoV-2 IgG positive cases were asymptomatic with no underlying illness, keeping case detection to a minimum.
Keywords: Coronavirus Infections; Ethiopia; Immunoglobulin G; Seroepidemiologic studies; blood; epidemiology.
. 2021 Aug 16;S1201-9712(21)00661-5.
doi: 10.1016/j.ijid.2021.08.028. Online ahead of print.
Seroprevalence and risk factors for SARS-CoV-2 Infection in selected urban areas in Ethiopia: a cross-sectional evaluation during July 2020
Enyew Birru Tadesse[SUP] 1 [/SUP], Abduilhafiz A Endris[SUP] 2 [/SUP], Henok Solomon[SUP] 2 [/SUP], Mikias Alayu[SUP] 2 [/SUP], Adisu Kebede[SUP] 2 [/SUP], Kirubel Eshetu[SUP] 2 [/SUP], Gizaw Teka[SUP] 2 [/SUP], Biniyam Eskinder Seid[SUP] 3 [/SUP], Jelaludin Ahmed[SUP] 3 [/SUP], Sisay Alemayehu Abayneh[SUP] 3 [/SUP], Beyene Mogesc Hizikiyas Gerawork[SUP] 4 [/SUP], David Sugerman[SUP] 3 [/SUP], Zewdu Assefa[SUP] 2 [/SUP], Aschalew Abayneh[SUP] 2 [/SUP], Ebba Abate[SUP] 2 [/SUP], Lia Taddese[SUP] 2 [/SUP]
Affiliations
- PMID: 34411720
- DOI: 10.1016/j.ijid.2021.08.028
Abstract
Background: Ethiopia reported the first case of COVID-19 on March 13[SUP]th[/SUP], 2020 with community transmission ensue by mid-May. National, population-based serosurvey against anti-SARS-CoV-2 IgG was conducted to measure the prevalence of prior COVID-19 infections and better approximate the burden across major towns in Ethiopia.
Methods: We conducted a cross-sectional, population-based serosurvey from June 24 to July 8, 2020 in 14 major urban areas. Two-stage cluster sampling was used to randomly select enumeration areas and households. All persons aged ≥15 years were enrolled. Serum samples tested by Abbott™ ARCHITECT™ assay for SARS-CoV-2 IgG antibodies. National COVID-19 surveillance data on the median date of the serosurvey is analyzed for comparison.
Findings: Adjusted seroprevalence was 3.5% (95% CI: 3.2%-3.8%) after controlling for age, sex and test kit performance. Males (3.7%) and females (3.3%) were nearly equally infected, while middle-aged adults 40-65 years had the highest (4.0%) prevalence. Gambella (7.5%), Dire Dawa (6.2%) and Jigjiga (6.1%) were most affected towns. About 6.7% and 8.0% of seropositives had symptoms and chronic underlying illness, respectively. Surveillance system had identified 4,416 RT-PCR confirmed cases in Addis Ababa.
Interpretation: This serosurvey shows majority of urban Ethiopians remain uninfected with SARS-CoV-2. Most anti-SARS-CoV-2 IgG positive cases were asymptomatic with no underlying illness, keeping case detection to a minimum.
Keywords: Coronavirus Infections; Ethiopia; Immunoglobulin G; Seroepidemiologic studies; blood; epidemiology.