tetano
Editor, Senior Moderator
Int J Infect Dis
. 2021 Feb 26;S1201-9712(21)00186-7.
doi: 10.1016/j.ijid.2021.02.100. Online ahead of print.
The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19
Marwa Ali Almadhi[SUP] 1 [/SUP], Abdulkarim Abdulrahman[SUP] 2 [/SUP], Sayed Ali Sharaf[SUP] 1 [/SUP], Dana AlSaad[SUP] 1 [/SUP], Nigel J Stevenson[SUP] 3 [/SUP], Stephen L Atkin[SUP] 3 [/SUP], Manaf M AlQahtani[SUP] 4 [/SUP]
Affiliations
Abstract
Purpose: The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread. However, evidence is accruing that asymptomatic individuals are infectious and contributing to this global pandemic.
Methods: Observational data of 320 index cases and their 1289 positive contacts from the National COVID-19 Database in Bahrain were used to analyse symptoms, infectivity rate and PCR Ct-values.
Results: No significant difference (p = 1.0) in proportions of symptomatic (n = 160; 50.0%) and asymptomatic index cases (n = 160; 50.0%) were seen; however, SARS-CoV-2 positive contact cases were predominantly asymptomatic (n = 1127, 87.4%). Individuals aged 0-19 constituted a larger proportion of positive contact cases (20.8%), than index cases (4.7%; p < 0.001). 22% of the positive contacts were infected by symptomatic male index cases aged between 30-39 years. The total number of exposed contacts (p = 0.33), infected contacts (p = 0.81) and hence infectivity rate (p = 0.72) were not different between symptomatic and asymptomatic index cases. PCR Ct-values were higher in asymptomatic compared to symptomatic index cases (p < 0.001), and higher in asymptomatic compared to symptomatic positive contacts (p < 0.001). No difference between the infectivity rates of index cases with Ct-values <30 and values ≥ 30 was observed (p = 0.13).
Conclusion: These data reveal that the high asymptomatic incidence of SARS-CoV-2 infection in Bahrain, and subsequent positive contacts from an index case are more likely to be asymptomatic showing the high "silent" risk of transmission and the need for comprehensive screening for each positive infection to help halt the ongoing pandemic.
Keywords: Bahrain; COVID-19; Cycle Threshold; Public Health; SARS-CoV-2; Transmission; asymptomatic; pandemic; symptomatic.
Copyright ? 2021. Published by Elsevier Ltd.
. 2021 Feb 26;S1201-9712(21)00186-7.
doi: 10.1016/j.ijid.2021.02.100. Online ahead of print.
The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19
Marwa Ali Almadhi[SUP] 1 [/SUP], Abdulkarim Abdulrahman[SUP] 2 [/SUP], Sayed Ali Sharaf[SUP] 1 [/SUP], Dana AlSaad[SUP] 1 [/SUP], Nigel J Stevenson[SUP] 3 [/SUP], Stephen L Atkin[SUP] 3 [/SUP], Manaf M AlQahtani[SUP] 4 [/SUP]
Affiliations
- PMID: 33647516
- DOI: 10.1016/j.ijid.2021.02.100
Abstract
Purpose: The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread. However, evidence is accruing that asymptomatic individuals are infectious and contributing to this global pandemic.
Methods: Observational data of 320 index cases and their 1289 positive contacts from the National COVID-19 Database in Bahrain were used to analyse symptoms, infectivity rate and PCR Ct-values.
Results: No significant difference (p = 1.0) in proportions of symptomatic (n = 160; 50.0%) and asymptomatic index cases (n = 160; 50.0%) were seen; however, SARS-CoV-2 positive contact cases were predominantly asymptomatic (n = 1127, 87.4%). Individuals aged 0-19 constituted a larger proportion of positive contact cases (20.8%), than index cases (4.7%; p < 0.001). 22% of the positive contacts were infected by symptomatic male index cases aged between 30-39 years. The total number of exposed contacts (p = 0.33), infected contacts (p = 0.81) and hence infectivity rate (p = 0.72) were not different between symptomatic and asymptomatic index cases. PCR Ct-values were higher in asymptomatic compared to symptomatic index cases (p < 0.001), and higher in asymptomatic compared to symptomatic positive contacts (p < 0.001). No difference between the infectivity rates of index cases with Ct-values <30 and values ≥ 30 was observed (p = 0.13).
Conclusion: These data reveal that the high asymptomatic incidence of SARS-CoV-2 infection in Bahrain, and subsequent positive contacts from an index case are more likely to be asymptomatic showing the high "silent" risk of transmission and the need for comprehensive screening for each positive infection to help halt the ongoing pandemic.
Keywords: Bahrain; COVID-19; Cycle Threshold; Public Health; SARS-CoV-2; Transmission; asymptomatic; pandemic; symptomatic.
Copyright ? 2021. Published by Elsevier Ltd.