tetano
Editor, Senior Moderator
Int J Infect Dis
. 2022 Jul 7;S1201-9712(22)00409-X.
doi: 10.1016/j.ijid.2022.07.014. Online ahead of print.
U-shaped association between abnormal serum uric acid levels and COVID-19 severity: Reports from the Japan COVID-19 Task Force
Takahiro Fukushima[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 3 [/SUP], Norihiro Harada[SUP] 4 [/SUP], Tetsuya Ueda[SUP] 5 [/SUP], Soichiro Ueda[SUP] 6 [/SUP], Takashi Ishiguro[SUP] 7 [/SUP], Ken Arimura[SUP] 8 [/SUP], Fukuki Saito[SUP] 9 [/SUP], Takashi Yoshiyama[SUP] 10 [/SUP], Yasushi Nakano[SUP] 11 [/SUP], Yoshikazu Mutoh[SUP] 12 [/SUP], Yusuke Suzuki[SUP] 13 [/SUP], Koji Murakami[SUP] 14 [/SUP], Yukinori Okada[SUP] 15 [/SUP], Ryuji Koike[SUP] 16 [/SUP], Yuko Kitagawa[SUP] 17 [/SUP], Akinori Kimura[SUP] 18 [/SUP], Seiya Imoto[SUP] 19 [/SUP], Satoru Miyano[SUP] 20 [/SUP], Seishi Ogawa[SUP] 21 [/SUP], Takanori Kanai[SUP] 22 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP], Japan COVID-19 Task Force
Affiliations
Abstract
Objectives: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and coronavirus disease 2019 (COVID-19) severity in the Japanese population.
Methods: We included 1,523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including comorbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.
Results: Patients with high serum uric acid levels were older and had higher body weights and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio (OR)=1.77; p=0.03/OR=1.56; p=0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR=5.09; p<0.0001).
Conclusion: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
Keywords: COVID-19; high serum uric acid; hyperuricemia; hypouricemia; low serum uric acid; respiratory care; severity.
. 2022 Jul 7;S1201-9712(22)00409-X.
doi: 10.1016/j.ijid.2022.07.014. Online ahead of print.
U-shaped association between abnormal serum uric acid levels and COVID-19 severity: Reports from the Japan COVID-19 Task Force
Takahiro Fukushima[SUP] 1 [/SUP], Shotaro Chubachi[SUP] 2 [/SUP], Ho Namkoong[SUP] 1 [/SUP], Shiro Otake[SUP] 1 [/SUP], Kensuke Nakagawara[SUP] 1 [/SUP], Hiromu Tanaka[SUP] 1 [/SUP], Ho Lee[SUP] 1 [/SUP], Atsuho Morita[SUP] 1 [/SUP], Mayuko Watase[SUP] 1 [/SUP], Tatsuya Kusumoto[SUP] 1 [/SUP], Katsunori Masaki[SUP] 1 [/SUP], Hirofumi Kamata[SUP] 1 [/SUP], Makoto Ishii[SUP] 1 [/SUP], Naoki Hasegawa[SUP] 3 [/SUP], Norihiro Harada[SUP] 4 [/SUP], Tetsuya Ueda[SUP] 5 [/SUP], Soichiro Ueda[SUP] 6 [/SUP], Takashi Ishiguro[SUP] 7 [/SUP], Ken Arimura[SUP] 8 [/SUP], Fukuki Saito[SUP] 9 [/SUP], Takashi Yoshiyama[SUP] 10 [/SUP], Yasushi Nakano[SUP] 11 [/SUP], Yoshikazu Mutoh[SUP] 12 [/SUP], Yusuke Suzuki[SUP] 13 [/SUP], Koji Murakami[SUP] 14 [/SUP], Yukinori Okada[SUP] 15 [/SUP], Ryuji Koike[SUP] 16 [/SUP], Yuko Kitagawa[SUP] 17 [/SUP], Akinori Kimura[SUP] 18 [/SUP], Seiya Imoto[SUP] 19 [/SUP], Satoru Miyano[SUP] 20 [/SUP], Seishi Ogawa[SUP] 21 [/SUP], Takanori Kanai[SUP] 22 [/SUP], Koichi Fukunaga[SUP] 1 [/SUP], Japan COVID-19 Task Force
Affiliations
- PMID: 35811077
- DOI: 10.1016/j.ijid.2022.07.014
Abstract
Objectives: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and coronavirus disease 2019 (COVID-19) severity in the Japanese population.
Methods: We included 1,523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including comorbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia.
Results: Patients with high serum uric acid levels were older and had higher body weights and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio (OR)=1.77; p=0.03/OR=1.56; p=0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR=5.09; p<0.0001).
Conclusion: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
Keywords: COVID-19; high serum uric acid; hyperuricemia; hypouricemia; low serum uric acid; respiratory care; severity.