tetano
Editor, Senior Moderator
Int J Obes (Lond)
. 2020 Jun 22.
doi: 10.1038/s41366-020-0634-3. Online ahead of print.
Clinical Epidemiological Analyses of overweight/obesity and Abnormal Liver Function Contributing to Prolonged Hospitalization in Patients Infected With COVID-19
Xiang Hu[SUP] 1 [/SUP], Xiaoqiong Pan[SUP] 2 [/SUP], Wei Zhou[SUP] 3 [/SUP], Xuejiang Gu[SUP] 1 [/SUP], Feixia Shen[SUP] 1 [/SUP], Bo Yang[SUP] 4 [/SUP], Zhen Hu[SUP] 5 [/SUP]
Affiliations
Abstract
Background/objectives: During the 2019 coronavirus disease (COVID-19) outbreak, obesity may contribute to COVID-19 transmission and deterioration. In addition, many patients with COVID-19 infection have suffered liver damage which might contribute to a worse prognosis. We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19.
Subjects/methods: Fifty-eight patients with diagnosed COVID-19 (22 women & 36 men; average age: 49.2 ? 13.1 yr) were included, and their clinical data were collected at The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang. Overweight/obesity was determined as body mass index (BMI) ≥24 kg/m[SUP]2[/SUP], ALF was determined as alanine aminotransferase >40 U/L, and prolonged hospitalization was lasting more than the median value of the hospitalized days (19 days) in this population.
Results: The proportions of prolonged hospitalization were elevated in patients with overweight/obesity and ALF compared with those without overweight/obesity (62.1% versus 26.1%, P = 0.010) and those without ALF (70.6% versus 41.5%, P = 0.043). Kaplan-Meier analysis showed that the hospitalized duration was increased from the patients with neither overweight/obesity nor ALF to those with either overweight/obesity or ALF, and to those with both of overweight/obesity and ALF (mean with 95% confidence interval: 16.4 [14.5-18.3] versus 25.3 [21.6-29.1] versus 28.3 [24.6-32.0], P for trend = 0.001). Being discharged from hospital in time was inversely and independently associated with BMI (hazard ratio
= 0.75, 95% CI: 0.63-0.90, P for trend = 0.002) and ALT (HR = 0.95, 95% CI: 0.92-0.99, P for trend = 0.007).
Conclusions: Present findings suggested that overweight/obesity and/or ALF contributed to predicting a probability of prolonged hospitalization in patients with COVID-19 infection, to whom extra attentions and precautions should be paid during clinical treatments.
. 2020 Jun 22.
doi: 10.1038/s41366-020-0634-3. Online ahead of print.
Clinical Epidemiological Analyses of overweight/obesity and Abnormal Liver Function Contributing to Prolonged Hospitalization in Patients Infected With COVID-19
Xiang Hu[SUP] 1 [/SUP], Xiaoqiong Pan[SUP] 2 [/SUP], Wei Zhou[SUP] 3 [/SUP], Xuejiang Gu[SUP] 1 [/SUP], Feixia Shen[SUP] 1 [/SUP], Bo Yang[SUP] 4 [/SUP], Zhen Hu[SUP] 5 [/SUP]
Affiliations
- PMID: 32572128
- DOI: 10.1038/s41366-020-0634-3
Abstract
Background/objectives: During the 2019 coronavirus disease (COVID-19) outbreak, obesity may contribute to COVID-19 transmission and deterioration. In addition, many patients with COVID-19 infection have suffered liver damage which might contribute to a worse prognosis. We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19.
Subjects/methods: Fifty-eight patients with diagnosed COVID-19 (22 women & 36 men; average age: 49.2 ? 13.1 yr) were included, and their clinical data were collected at The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang. Overweight/obesity was determined as body mass index (BMI) ≥24 kg/m[SUP]2[/SUP], ALF was determined as alanine aminotransferase >40 U/L, and prolonged hospitalization was lasting more than the median value of the hospitalized days (19 days) in this population.
Results: The proportions of prolonged hospitalization were elevated in patients with overweight/obesity and ALF compared with those without overweight/obesity (62.1% versus 26.1%, P = 0.010) and those without ALF (70.6% versus 41.5%, P = 0.043). Kaplan-Meier analysis showed that the hospitalized duration was increased from the patients with neither overweight/obesity nor ALF to those with either overweight/obesity or ALF, and to those with both of overweight/obesity and ALF (mean with 95% confidence interval: 16.4 [14.5-18.3] versus 25.3 [21.6-29.1] versus 28.3 [24.6-32.0], P for trend = 0.001). Being discharged from hospital in time was inversely and independently associated with BMI (hazard ratio
= 0.75, 95% CI: 0.63-0.90, P for trend = 0.002) and ALT (HR = 0.95, 95% CI: 0.92-0.99, P for trend = 0.007).
Conclusions: Present findings suggested that overweight/obesity and/or ALF contributed to predicting a probability of prolonged hospitalization in patients with COVID-19 infection, to whom extra attentions and precautions should be paid during clinical treatments.