tetano
Editor, Senior Moderator
Int J Public Health
. 2022 May 11;67:1604427.
doi: 10.3389/ijph.2022.1604427. eCollection 2022.
The First 110,593 COVID-19 Patients Hospitalised in Lombardy: A Regionwide Analysis of Case Characteristics, Risk Factors and Clinical Outcomes
Nicole Mauer[SUP] 1 2 [/SUP], Greta Chiecca[SUP] 1 [/SUP], Greta Carioli[SUP] 1 [/SUP], Vincenza Gianfredi[SUP] 3 [/SUP], Licia Iacoviello[SUP] 4 5 [/SUP], Silvia Bertagnolio[SUP] 6 [/SUP], Ranieri Guerra[SUP] 6 [/SUP], Anna Odone[SUP] 7 [/SUP], Carlo Signorelli[SUP] 1 [/SUP]
Affiliations
Abstract
Objectives: To describe the monthly distribution of COVID-19 hospitalisations, deaths and case-fatality rates (CFR) in Lombardy (Italy) throughout 2020. Methods: We analysed de-identified hospitalisation data comprising all COVID-19-related admissions from 1 February 2020 to 31 December 2020. The overall survival (OS) from time of first hospitalisation was estimated using the Kaplan-Meier method. We estimated monthly CFRs and performed Cox regression models to measure the effects of potential predictors on OS. Results: Hospitalisation and death peaks occurred in March and November 2020. Patients aged ≥70 years had an up to 180 times higher risk of dying compared to younger patients [70-80: HR 58.10 (39.14-86.22); 80-90: 106.68 (71.01-160.27); ≥90: 180.96 (118.80-275.64)]. Risk of death was higher in patients with one or more comorbidities [1: HR 1.27 (95% CI 1.20-1.35); 2: 1.44 (1.33-1.55); ≥3: 1.73 (1.58-1.90)] and in those with specific conditions (hypertension, diabetes). Conclusion: Our data sheds light on the Italian pandemic scenario, uncovering mechanisms and gaps at regional health system level and, on a larger scale, adding to the body of knowledge needed to inform effective health service planning, delivery, and preparedness in times of crisis.
Keywords: COVID-19; Coronavirus disease; Italy; Lombardy; SARS-CoV-2; epidemiology; hospital admission statistics; hospital records.
. 2022 May 11;67:1604427.
doi: 10.3389/ijph.2022.1604427. eCollection 2022.
The First 110,593 COVID-19 Patients Hospitalised in Lombardy: A Regionwide Analysis of Case Characteristics, Risk Factors and Clinical Outcomes
Nicole Mauer[SUP] 1 2 [/SUP], Greta Chiecca[SUP] 1 [/SUP], Greta Carioli[SUP] 1 [/SUP], Vincenza Gianfredi[SUP] 3 [/SUP], Licia Iacoviello[SUP] 4 5 [/SUP], Silvia Bertagnolio[SUP] 6 [/SUP], Ranieri Guerra[SUP] 6 [/SUP], Anna Odone[SUP] 7 [/SUP], Carlo Signorelli[SUP] 1 [/SUP]
Affiliations
- PMID: 35645700
- PMCID: PMC9131487
- DOI: 10.3389/ijph.2022.1604427
Abstract
Objectives: To describe the monthly distribution of COVID-19 hospitalisations, deaths and case-fatality rates (CFR) in Lombardy (Italy) throughout 2020. Methods: We analysed de-identified hospitalisation data comprising all COVID-19-related admissions from 1 February 2020 to 31 December 2020. The overall survival (OS) from time of first hospitalisation was estimated using the Kaplan-Meier method. We estimated monthly CFRs and performed Cox regression models to measure the effects of potential predictors on OS. Results: Hospitalisation and death peaks occurred in March and November 2020. Patients aged ≥70 years had an up to 180 times higher risk of dying compared to younger patients [70-80: HR 58.10 (39.14-86.22); 80-90: 106.68 (71.01-160.27); ≥90: 180.96 (118.80-275.64)]. Risk of death was higher in patients with one or more comorbidities [1: HR 1.27 (95% CI 1.20-1.35); 2: 1.44 (1.33-1.55); ≥3: 1.73 (1.58-1.90)] and in those with specific conditions (hypertension, diabetes). Conclusion: Our data sheds light on the Italian pandemic scenario, uncovering mechanisms and gaps at regional health system level and, on a larger scale, adding to the body of knowledge needed to inform effective health service planning, delivery, and preparedness in times of crisis.
Keywords: COVID-19; Coronavirus disease; Italy; Lombardy; SARS-CoV-2; epidemiology; hospital admission statistics; hospital records.