tetano
Editor, Senior Moderator
Int Psychogeriatr
. 2021 Sep 23;1-5.
doi: 10.1017/S104161022100106X. Online ahead of print.
Delirium occurrence and association with outcomes in hospitalized COVID-19 patients
Sandeep Pagali[SUP] 1 [/SUP], Sunyang Fu[SUP] 2 [/SUP], Heidi Lindroth[SUP] 3 [/SUP], Sunghwan Sohn[SUP] 4 [/SUP], M Caroline Burton[SUP] 5 [/SUP], Maria Lapid[SUP] 6 [/SUP]
Affiliations
Abstract
Delirium is reported to be one of the manifestations of coronavirus infectious disease 2019 (COVID-19) infection. COVID-19 hospitalized patients are at a higher risk of delirium. Pathophysiology behind the association of delirium and COVID-19 is uncertain. We analyzed the association of delirium occurrence with outcomes in hospitalized COVID-19 patients, across all age groups, at Mayo Clinic hospitals.A retrospective study of all hospitalized COVID-19 patients at Mayo Clinic between March 1, 2020 and December 31, 2020 was performed. Occurrence of delirium and outcomes of mortality, length of stay, readmission, and 30-day mortality after hospital discharge were measured. Chi-square test, student t-test, survival analysis, and logistic regression analysis were performed to measure and compare outcomes of delirium group adjusted for age, sex, Charlson comorbidity score, and COVID-19 severity with no-delirium group.A total of 4351 COVID-19 patients were included in the study. Delirium occurrence in the overall study population was noted to be 22.4%. The highest occurrence of delirium was also noted in patients with critical COVID-19 illness severity. A statistically significant OR 4.35 (3.27-5.83) for in-hospital mortality and an OR 4.54 (3.25-6.38) for 30-day mortality after discharge in the delirium group were noted. Increased hospital length of stay, 30-day readmission, and need for skilled nursing facility on discharge were noted in the delirium group. Delirium in hospitalized COVID-19 patients is a marker for increased mortality and morbidity. In this group, outcomes appear to be much worse when patients are older and have a critical severity of COVID-19 illness.
Keywords: COVID-19 severity; delirium; hospitalized COVID-19; outcomes.
. 2021 Sep 23;1-5.
doi: 10.1017/S104161022100106X. Online ahead of print.
Delirium occurrence and association with outcomes in hospitalized COVID-19 patients
Sandeep Pagali[SUP] 1 [/SUP], Sunyang Fu[SUP] 2 [/SUP], Heidi Lindroth[SUP] 3 [/SUP], Sunghwan Sohn[SUP] 4 [/SUP], M Caroline Burton[SUP] 5 [/SUP], Maria Lapid[SUP] 6 [/SUP]
Affiliations
- PMID: 34551841
- DOI: 10.1017/S104161022100106X
Abstract
Delirium is reported to be one of the manifestations of coronavirus infectious disease 2019 (COVID-19) infection. COVID-19 hospitalized patients are at a higher risk of delirium. Pathophysiology behind the association of delirium and COVID-19 is uncertain. We analyzed the association of delirium occurrence with outcomes in hospitalized COVID-19 patients, across all age groups, at Mayo Clinic hospitals.A retrospective study of all hospitalized COVID-19 patients at Mayo Clinic between March 1, 2020 and December 31, 2020 was performed. Occurrence of delirium and outcomes of mortality, length of stay, readmission, and 30-day mortality after hospital discharge were measured. Chi-square test, student t-test, survival analysis, and logistic regression analysis were performed to measure and compare outcomes of delirium group adjusted for age, sex, Charlson comorbidity score, and COVID-19 severity with no-delirium group.A total of 4351 COVID-19 patients were included in the study. Delirium occurrence in the overall study population was noted to be 22.4%. The highest occurrence of delirium was also noted in patients with critical COVID-19 illness severity. A statistically significant OR 4.35 (3.27-5.83) for in-hospital mortality and an OR 4.54 (3.25-6.38) for 30-day mortality after discharge in the delirium group were noted. Increased hospital length of stay, 30-day readmission, and need for skilled nursing facility on discharge were noted in the delirium group. Delirium in hospitalized COVID-19 patients is a marker for increased mortality and morbidity. In this group, outcomes appear to be much worse when patients are older and have a critical severity of COVID-19 illness.
Keywords: COVID-19 severity; delirium; hospitalized COVID-19; outcomes.