tetano
Editor, Senior Moderator
Intern Med
. 2023 Nov 13.
doi: 10.2169/internalmedicine.2751-23. Online ahead of print. A Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following SARS-CoV-2 Infection
Masateru Tajiri[SUP] 1 [/SUP], Ken Takasone[SUP] 1 [/SUP], Minori Kodaira[SUP] 1 [/SUP], Akio Kimura[SUP] 2 [/SUP], Takayoshi Shimohata[SUP] 2 [/SUP], Yoshiki Sekijima[SUP] 1 3 [/SUP]
Affiliations
We herein report the first case of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy after coronavirus disease 2019 (COVID-19). A 23-year-old man experienced fatigue, a fever, and headache 14 days after the resolution of COVID-19. He was severely disoriented and admitted to our hospital. On admission, the patient exhibited disorientation, headache, neck stiffness, myoclonus of both upper limbs, dysuria, and pyramidal signs. A blood examination revealed hyponatremia, and a cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis. The CSF test results were positive for anti-GFAPα antibodies. The patient was treated with methylprednisolone pulse therapy, followed by oral prednisolone, which quickly ameliorated his neurological abnormalities.
Keywords: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy; coronavirus disease 2019 (COVID-19); encephalomyelitis.
. 2023 Nov 13.
doi: 10.2169/internalmedicine.2751-23. Online ahead of print. A Case of Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy Following SARS-CoV-2 Infection
Masateru Tajiri[SUP] 1 [/SUP], Ken Takasone[SUP] 1 [/SUP], Minori Kodaira[SUP] 1 [/SUP], Akio Kimura[SUP] 2 [/SUP], Takayoshi Shimohata[SUP] 2 [/SUP], Yoshiki Sekijima[SUP] 1 3 [/SUP]
Affiliations
- PMID: 37952950
- DOI: 10.2169/internalmedicine.2751-23
We herein report the first case of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy after coronavirus disease 2019 (COVID-19). A 23-year-old man experienced fatigue, a fever, and headache 14 days after the resolution of COVID-19. He was severely disoriented and admitted to our hospital. On admission, the patient exhibited disorientation, headache, neck stiffness, myoclonus of both upper limbs, dysuria, and pyramidal signs. A blood examination revealed hyponatremia, and a cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis. The CSF test results were positive for anti-GFAPα antibodies. The patient was treated with methylprednisolone pulse therapy, followed by oral prednisolone, which quickly ameliorated his neurological abnormalities.
Keywords: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy; coronavirus disease 2019 (COVID-19); encephalomyelitis.