tetano
Editor, Senior Moderator
Intern Med
. 2022 Feb 8.
doi: 10.2169/internalmedicine.9004-21. Online ahead of print.
A Case of New-onset Type 1 Diabetes after Covid-19 mRNA Vaccination
Masahiro Yano[SUP] 1 [/SUP], Tomoaki Morioka[SUP] 1 [/SUP], Yuka Natsuki[SUP] 1 [/SUP], Keyaki Sasaki[SUP] 1 [/SUP], Yoshinori Kakutani[SUP] 1 [/SUP], Akinobu Ochi[SUP] 1 [/SUP], Yuko Yamazaki[SUP] 1 [/SUP], Tetsuo Shoji[SUP] 2 [/SUP], Masanori Emoto[SUP] 1 [/SUP]
Affiliations
Abstract
During the ongoing coronavirus disease 2019 (Covid-19) pandemic, it is critical to ensure the safety of Covid-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a Covid-19 mRNA vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that Covid-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition.
Keywords: Covid-19; SARS-CoV-2; autoimmunity; hyperglycemia; mRNA vaccine; type 1 diabetes.
. 2022 Feb 8.
doi: 10.2169/internalmedicine.9004-21. Online ahead of print.
A Case of New-onset Type 1 Diabetes after Covid-19 mRNA Vaccination
Masahiro Yano[SUP] 1 [/SUP], Tomoaki Morioka[SUP] 1 [/SUP], Yuka Natsuki[SUP] 1 [/SUP], Keyaki Sasaki[SUP] 1 [/SUP], Yoshinori Kakutani[SUP] 1 [/SUP], Akinobu Ochi[SUP] 1 [/SUP], Yuko Yamazaki[SUP] 1 [/SUP], Tetsuo Shoji[SUP] 2 [/SUP], Masanori Emoto[SUP] 1 [/SUP]
Affiliations
- PMID: 35135929
- DOI: 10.2169/internalmedicine.9004-21
Abstract
During the ongoing coronavirus disease 2019 (Covid-19) pandemic, it is critical to ensure the safety of Covid-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a Covid-19 mRNA vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that Covid-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition.
Keywords: Covid-19; SARS-CoV-2; autoimmunity; hyperglycemia; mRNA vaccine; type 1 diabetes.