tetano
Editor, Senior Moderator
Intern Med
. 2023 May 24.
doi: 10.2169/internalmedicine.1399-22. Online ahead of print. A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron variants in Japan: A Retrospective Study
Ryutaro Hirama[SUP] 1 [/SUP], Kenichiro Takeda[SUP] 1 [/SUP], Seiichiro Sakao[SUP] 1 [/SUP], Hajime Kasai[SUP] 1 2 3 [/SUP], Shizu Miyata[SUP] 1 [/SUP], Kohei Shikano[SUP] 1 [/SUP], Akira Naito[SUP] 1 [/SUP], Mitsuhiro Abe[SUP] 1 [/SUP], Takeshi Kawasaki[SUP] 1 [/SUP], Ayako Shigeta[SUP] 1 [/SUP], Taka-Aki Nakada[SUP] 4 [/SUP], Hidetoshi Igari[SUP] 5 [/SUP], Takuji Suzuki[SUP] 1 [/SUP]
Affiliations
Objective We evaluated the clinical differences in coronavirus disease 2019 (COVID-19) patients between the sixth wave with the Omicron BA.1/BA.2 dominant variant (from January to April 2022) and seventh wave with the Omicron BA.5 dominant variant (from July to August 2022). Methods This retrospective, single-center, observational study included COVID-19 patients admitted to our institution in the sixth wave (sixth-wave group) and the seventh wave (seventh-wave group). Inter-group comparisons of clinical presentations, the prognosis, and proportion of nosocomial infections were performed. Results A total of 190 patients were included (93 and 97 patients in the sixth- and seventh-wave groups, respectively). While there were no significant differences in severity, significantly more patients developed pneumonia caused by COVID-19 in the sixth-wave group than in the seventh-wave group. Although there was no marked difference in in-hospital deaths, more patients died from COVID-19 in the sixth-wave group than in the seventh-wave group. There were significantly more COVID-19 inpatients with nosocomial infections in the seventh-wave group than in the sixth-wave group. Pneumonia from COVID-19 was significantly more severe in the sixth-wave group than in the seventh-wave group. Conclusions COVID-19 patients in the seventh wave are at a lower risk of pneumonia than those in the sixth wave. However, even in the seventh wave, patients with underlying diseases have a risk of death because of the exacerbation of underlying diseases triggered by COVID-19.
Keywords: coronavirus disease 2019; nosocomial infection; omicron variant; pneumonia.
. 2023 May 24.
doi: 10.2169/internalmedicine.1399-22. Online ahead of print. A Comparison of Clinical Presentations in Coronavirus Disease 2019 Caused by Different Omicron variants in Japan: A Retrospective Study
Ryutaro Hirama[SUP] 1 [/SUP], Kenichiro Takeda[SUP] 1 [/SUP], Seiichiro Sakao[SUP] 1 [/SUP], Hajime Kasai[SUP] 1 2 3 [/SUP], Shizu Miyata[SUP] 1 [/SUP], Kohei Shikano[SUP] 1 [/SUP], Akira Naito[SUP] 1 [/SUP], Mitsuhiro Abe[SUP] 1 [/SUP], Takeshi Kawasaki[SUP] 1 [/SUP], Ayako Shigeta[SUP] 1 [/SUP], Taka-Aki Nakada[SUP] 4 [/SUP], Hidetoshi Igari[SUP] 5 [/SUP], Takuji Suzuki[SUP] 1 [/SUP]
Affiliations
- PMID: 37225494
- DOI: 10.2169/internalmedicine.1399-22
Objective We evaluated the clinical differences in coronavirus disease 2019 (COVID-19) patients between the sixth wave with the Omicron BA.1/BA.2 dominant variant (from January to April 2022) and seventh wave with the Omicron BA.5 dominant variant (from July to August 2022). Methods This retrospective, single-center, observational study included COVID-19 patients admitted to our institution in the sixth wave (sixth-wave group) and the seventh wave (seventh-wave group). Inter-group comparisons of clinical presentations, the prognosis, and proportion of nosocomial infections were performed. Results A total of 190 patients were included (93 and 97 patients in the sixth- and seventh-wave groups, respectively). While there were no significant differences in severity, significantly more patients developed pneumonia caused by COVID-19 in the sixth-wave group than in the seventh-wave group. Although there was no marked difference in in-hospital deaths, more patients died from COVID-19 in the sixth-wave group than in the seventh-wave group. There were significantly more COVID-19 inpatients with nosocomial infections in the seventh-wave group than in the sixth-wave group. Pneumonia from COVID-19 was significantly more severe in the sixth-wave group than in the seventh-wave group. Conclusions COVID-19 patients in the seventh wave are at a lower risk of pneumonia than those in the sixth wave. However, even in the seventh wave, patients with underlying diseases have a risk of death because of the exacerbation of underlying diseases triggered by COVID-19.
Keywords: coronavirus disease 2019; nosocomial infection; omicron variant; pneumonia.