tetano
Editor, Senior Moderator
Intern Med
. 2023;62(16):2381-2387.
doi: 10.2169/internalmedicine.1631-23. Epub 2023 Aug 15. Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
Erika Hishida[SUP] 1 [/SUP], Yuko Ono[SUP] 2 [/SUP], Kazuho Oe[SUP] 1 [/SUP], Toshimi Imai[SUP] 1 [/SUP], Hiromichi Yoshizawa[SUP] 1 [/SUP], Takeo Nakaya[SUP] 3 [/SUP], Hirotoshi Kawata[SUP] 3 [/SUP], Tetsu Akimoto[SUP] 1 [/SUP], Osamu Saito[SUP] 1 [/SUP], Daisuke Nagata[SUP] 1 [/SUP]
Affiliations
We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.
Keywords: COVID-19; SARS-CoV-2; acute interstitial nephritis; acute kidney injury; capillary IgA deposition; vaccination.
. 2023;62(16):2381-2387.
doi: 10.2169/internalmedicine.1631-23. Epub 2023 Aug 15. Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination
Erika Hishida[SUP] 1 [/SUP], Yuko Ono[SUP] 2 [/SUP], Kazuho Oe[SUP] 1 [/SUP], Toshimi Imai[SUP] 1 [/SUP], Hiromichi Yoshizawa[SUP] 1 [/SUP], Takeo Nakaya[SUP] 3 [/SUP], Hirotoshi Kawata[SUP] 3 [/SUP], Tetsu Akimoto[SUP] 1 [/SUP], Osamu Saito[SUP] 1 [/SUP], Daisuke Nagata[SUP] 1 [/SUP]
Affiliations
- PMID: 37587055
- DOI: 10.2169/internalmedicine.1631-23
We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.
Keywords: COVID-19; SARS-CoV-2; acute interstitial nephritis; acute kidney injury; capillary IgA deposition; vaccination.