tetano
Editor, Senior Moderator
Intern Med
. 2023;62(4):589-593.
doi: 10.2169/internalmedicine.1109-22. Epub 2023 Feb 15.
Granulomatosis with Polyangiitis following COVID-19 in an Adolescent
Yume Nakamura[SUP] 1 2 [/SUP], Fumihiko Okumura[SUP] 1 2 [/SUP], Mayumi Nihei[SUP] 2 [/SUP], Kei Chubachi[SUP] 1 [/SUP], Hiroaki Sakamoto[SUP] 1 [/SUP], Yoshiko Ishioka[SUP] 1 [/SUP], Tomonori Makiguchi[SUP] 1 [/SUP], Hisashi Tanaka[SUP] 1 [/SUP], Kageaki Taima[SUP] 1 [/SUP], Nobuhisa Yajima[SUP] 3 [/SUP], Akira Kurose[SUP] 4 [/SUP], Sadatomo Tasaka[SUP] 1 [/SUP]
Affiliations
Abstract
Granulomatosis with polyangiitis (GPA) is a systemic disease that causes vasculitis in various organs. Although the mechanism of pathogenesis remains unclear, infection has been reported to be a causative factor. We herein report a case of GPA that developed following coronavirus disease 2019 (COVID-19) in an adolescent girl. One month after contracting mild COVID-19, the patient had facial allodynia, a fever, and weight loss and was admitted for multiple nodular shadows on a chest roentgenogram. GPA was diagnosed based on pathological findings of the lung and nasal mucosal biopsies. She received methylprednisolone and rituximab, and her symptoms and radiological findings improved.
Keywords: coronavirus disease 2019; facial allodynia; granulomatosis with polyangiitis; multiple lung nodules; proteinase-3-antineutrophil cytoplasmic antibody; rituximab.
. 2023;62(4):589-593.
doi: 10.2169/internalmedicine.1109-22. Epub 2023 Feb 15.
Granulomatosis with Polyangiitis following COVID-19 in an Adolescent
Yume Nakamura[SUP] 1 2 [/SUP], Fumihiko Okumura[SUP] 1 2 [/SUP], Mayumi Nihei[SUP] 2 [/SUP], Kei Chubachi[SUP] 1 [/SUP], Hiroaki Sakamoto[SUP] 1 [/SUP], Yoshiko Ishioka[SUP] 1 [/SUP], Tomonori Makiguchi[SUP] 1 [/SUP], Hisashi Tanaka[SUP] 1 [/SUP], Kageaki Taima[SUP] 1 [/SUP], Nobuhisa Yajima[SUP] 3 [/SUP], Akira Kurose[SUP] 4 [/SUP], Sadatomo Tasaka[SUP] 1 [/SUP]
Affiliations
- PMID: 36792217
- DOI: 10.2169/internalmedicine.1109-22
Abstract
Granulomatosis with polyangiitis (GPA) is a systemic disease that causes vasculitis in various organs. Although the mechanism of pathogenesis remains unclear, infection has been reported to be a causative factor. We herein report a case of GPA that developed following coronavirus disease 2019 (COVID-19) in an adolescent girl. One month after contracting mild COVID-19, the patient had facial allodynia, a fever, and weight loss and was admitted for multiple nodular shadows on a chest roentgenogram. GPA was diagnosed based on pathological findings of the lung and nasal mucosal biopsies. She received methylprednisolone and rituximab, and her symptoms and radiological findings improved.
Keywords: coronavirus disease 2019; facial allodynia; granulomatosis with polyangiitis; multiple lung nodules; proteinase-3-antineutrophil cytoplasmic antibody; rituximab.