tetano
Editor, Senior Moderator
Intern Med
. 2022 Mar 19.
doi: 10.2169/internalmedicine.9177-21. Online ahead of print.
Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
Takuto Shonai[SUP] 1 2 [/SUP], Fumihiko Kimura[SUP] 2 [/SUP], Junichi Watanabe[SUP] 1 [/SUP]
Affiliations
Abstract
We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP.
Keywords: COVID-19; immune thrombocytopenia; vaccination.
. 2022 Mar 19.
doi: 10.2169/internalmedicine.9177-21. Online ahead of print.
Severe Immune Thrombocytopenia after COVID-19 Vaccination: Two Case Reports and a Literature Review
Takuto Shonai[SUP] 1 2 [/SUP], Fumihiko Kimura[SUP] 2 [/SUP], Junichi Watanabe[SUP] 1 [/SUP]
Affiliations
- PMID: 35314552
- DOI: 10.2169/internalmedicine.9177-21
Abstract
We herein report two cases of coronavirus disease 2019 (COVID-19) vaccine-induced immune thrombocytopenia (ITP). A 69-year-old Japanese man developed severe thrombocytopenia after COVID-19 vaccination. He had oral bleeding and hemoptysis but no thrombotic symptoms. He improved rapidly with oral prednisolone therapy. A 34-year-old Japanese woman had generalized purpura after COVID-19 vaccination. Her platelet count improved rapidly after treatment with prednisolone and eltrombopag. The occurrence of two cases of ITP after COVID-19 vaccination at a single institution suggests that there could be more such undiagnosed cases, especially cases of mild secondary ITP.
Keywords: COVID-19; immune thrombocytopenia; vaccination.