tetano
Editor, Senior Moderator
Intern Med
. 2025 Mar 1.
doi: 10.2169/internalmedicine.4852-24. Online ahead of print. Spontaneous Remission in a Patient with Anti-OJ Autoantibodies-positive Anti-synthetase Syndrome Following SARS-CoV-2 Infection and mRNA Vaccination: A Case Report
Yasuyuki Todoroki[SUP] 1 2 [/SUP], Shingo Nakayamada[SUP] 1 [/SUP], Ippei Miyagawa[SUP] 1 [/SUP], Satoshi Kubo[SUP] 1 2 [/SUP], Kiyotake Yoshioka[SUP] 1 [/SUP], Minoru Satoh[SUP] 3 4 [/SUP], Yoshiya Tanaka[SUP] 1 [/SUP]
Affiliations
Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Cov-2 messenger RNA (mRNA) vaccination. Her dyspnea and rash resolved within 4 weeks of the initial examination, achieving spontaneous remission without treatment 52 weeks after the diagnosis. This case suggests a potential association between SARS-CoV-2 infection, mRNA vaccination, and the transient development of anti-OJ antibodies-positive ASyS.
Keywords: Anti-synthetase syndrome; SARS-CoV-2 infection; SARS-CoV-2 mRNA vaccination; Spontaneous remission.
. 2025 Mar 1.
doi: 10.2169/internalmedicine.4852-24. Online ahead of print. Spontaneous Remission in a Patient with Anti-OJ Autoantibodies-positive Anti-synthetase Syndrome Following SARS-CoV-2 Infection and mRNA Vaccination: A Case Report
Yasuyuki Todoroki[SUP] 1 2 [/SUP], Shingo Nakayamada[SUP] 1 [/SUP], Ippei Miyagawa[SUP] 1 [/SUP], Satoshi Kubo[SUP] 1 2 [/SUP], Kiyotake Yoshioka[SUP] 1 [/SUP], Minoru Satoh[SUP] 3 4 [/SUP], Yoshiya Tanaka[SUP] 1 [/SUP]
Affiliations
- PMID: 40024740
- DOI: 10.2169/internalmedicine.4852-24
Anti-synthetase syndrome (ASyS) is a subset of idiopathic inflammatory myopathies characterized by a triad of myositis, interstitial lung disease, and arthritis. Patients with ASyS are generally treated with glucocorticoids, immunosuppressants, or both. We encountered a 53-year-old woman who developed anti-OJ autoantibodies-positive anti-synthetase syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Cov-2 messenger RNA (mRNA) vaccination. Her dyspnea and rash resolved within 4 weeks of the initial examination, achieving spontaneous remission without treatment 52 weeks after the diagnosis. This case suggests a potential association between SARS-CoV-2 infection, mRNA vaccination, and the transient development of anti-OJ antibodies-positive ASyS.
Keywords: Anti-synthetase syndrome; SARS-CoV-2 infection; SARS-CoV-2 mRNA vaccination; Spontaneous remission.