tetano
Editor, Senior Moderator
Curr Opin Virol. 2013 Apr 4. pii: S1879-6257(13)00025-4. doi: 10.1016/j.coviro.2013.03.001. [Epub ahead of print]
Intervention strategies for emerging viruses: use of antivirals.
Debing Y, Jochmans D, Neyts J.
Source
Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
Abstract
Today, small molecule antiviral drugs are available for the treatment of infections with herpesviruses, HIV, HBV and HCV as well as with influenza viruses. Ribavirin, a broad-spectrum (but aspecific) antiviral, has been approved for the treatment of infections with respiratory syncytial virus, HCV and Lassa virus. Yet, for many other viruses that cause life-threatening infections [most of which are considered emerging and/or neglected] there are no drugs available. Ideally, potent and broad-spectrum (i.e., pan-genus or pan-family virus activity) antiviral drugs should be developed whereby one drug could be used for the treatment of a number of such viral infections. We here review recent evolutions in the search for inhibitors of emerging and neglected RNA viruses.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23562753
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23562753
Intervention strategies for emerging viruses: use of antivirals.
Debing Y, Jochmans D, Neyts J.
Source
Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium.
Abstract
Today, small molecule antiviral drugs are available for the treatment of infections with herpesviruses, HIV, HBV and HCV as well as with influenza viruses. Ribavirin, a broad-spectrum (but aspecific) antiviral, has been approved for the treatment of infections with respiratory syncytial virus, HCV and Lassa virus. Yet, for many other viruses that cause life-threatening infections [most of which are considered emerging and/or neglected] there are no drugs available. Ideally, potent and broad-spectrum (i.e., pan-genus or pan-family virus activity) antiviral drugs should be developed whereby one drug could be used for the treatment of a number of such viral infections. We here review recent evolutions in the search for inhibitors of emerging and neglected RNA viruses.
Copyright ? 2013 Elsevier B.V. All rights reserved.
PMID:
23562753
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23562753