tetano
Editor, Senior Moderator
Vaccine. 2014 Aug 12. pii: S0264-410X(14)01077-9. doi: 10.1016/j.vaccine.2014.07.095. [Epub ahead of print]
Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: A comparative effectiveness study using the Valencia health care information system.
Puig-Barber? J1, Natividad-Sancho A2, Calabuig-P?rez J3, Lluch-Rodrigo JA4, Pastor-Villalba E4, Mart?nez-?beda S2, D?ez-Domingo J2.
Author information
Abstract
BACKGROUND:
The use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.
METHODS:
We conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011-2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).
RESULTS:
Overall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50-0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52-0.85).
CONCLUSIONS:
During the 2011-2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Aged; Cohort studies; Comparative effectiveness research; Hospitalization; Influenza vaccines
PMID:
25131737
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25131737
Intradermal and virosomal influenza vaccines for preventing influenza hospitalization in the elderly during the 2011-2012 influenza season: A comparative effectiveness study using the Valencia health care information system.
Puig-Barber? J1, Natividad-Sancho A2, Calabuig-P?rez J3, Lluch-Rodrigo JA4, Pastor-Villalba E4, Mart?nez-?beda S2, D?ez-Domingo J2.
Author information
Abstract
BACKGROUND:
The use of intradermal vaccination or virosomal vaccines could increase protection against influenza among the vulnerable population of older adults. Studies assessing the comparative effectiveness of these two influenza vaccine types in this age group are lacking.
METHODS:
We conducted a retrospective cohort study to estimate the comparative effectiveness of intradermal seasonal trivalent-influenza vaccine (TIV) delivered by a microneedle injection system and a virosomal-TIV intramuscularly delivered for prevention of influenza hospitalization in non-institutionalized adults aged ≥65 years. We obtained administrative data on immunization status and influenza hospitalization for the 2011-2012 influenza season, and used Cox regression models to assess comparative effectiveness. We estimated crude and adjusted (age, sex, comorbidity, pharmaceutical claims, recent pneumococcal vaccination and number of hospitalizations for all causes other than influenza between the previous and current influenza seasons) hazard ratios (HR).
RESULTS:
Overall, 164,021 vaccinated subjects were evaluated. There were 127 hospitalizations for influenza among 62,058 subjects, contributing 914,740 person-weeks at risk in the virosomal-TIV group, and 133 hospitalizations for influenza among 101,963 subjects, contributing 1,504,570 person-weeks at risk in the intradermal-TIV group. The crude HR of intradermal-TIV relative to virosomal-TIV was 0.64 (95% confidence interval (CI): 0.50-0.81), and the adjusted Cox estimated HR was 0.67 (95% CI: 0.52-0.85).
CONCLUSIONS:
During the 2011-2012 influenza season the risk of hospitalization for influenza was reduced by 33% in non-institutionalized elderly adults who were vaccinated with intradermal-TIV compared with virosomal-TIV.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Aged; Cohort studies; Comparative effectiveness research; Hospitalization; Influenza vaccines
PMID:
25131737
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25131737