tetano
Editor, Senior Moderator
Virol J. 2015 Oct 6;12(1):160. doi: 10.1186/s12985-015-0387-0.
[h=1]Intranasal administration of poly-gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection.[/h] Kim EH[SUP]1,[/SUP][SUP]2[/SUP], Choi YK[SUP]3[/SUP], Kim CJ[SUP]4[/SUP], Sung MH[SUP]5[/SUP], Poo H[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The global outbreak of a novel swine-origin strain of the 2009 H1N1 influenza A virus and the sudden, worldwide increase in oseltamivir-resistant H1N1 influenza A viruses highlight the urgent need for novel antiviral therapy.
[h=4]METHODS:[/h] Here, we investigated the antiviral efficacy of poly-gamma glutamate (γ-PGA), a safe and edible biomaterial that is naturally synthesized by Bacillus subtilis, against A/Puerto Rico/8/1934 (PR8) and A/California/04/2009 (CA04) H1N1 influenza A virus infections in C57BL/6 mice.
[h=4]RESULTS:[/h] Intranasal administration of γ-PGA for 5 days post-infection improved survival, increased production of antiviral cytokines including interferon-beta (IFN-β) and interleukin-12 (IL-12), and enhanced activation of natural killer (NK) cells and influenza antigen-specific cytotoxic T lymphocytes (CTL) activity.
[h=4]CONCLUSIONS:[/h] These results suggest that γ-PGA protects mice against H1N1 influenza A virus by enhancing antiviral immune responses.
PMID: 26437715 [PubMed - in process] PMCID: PMC4595321 Free PMC Article
[h=1]Intranasal administration of poly-gamma glutamate induced antiviral activity and protective immune responses against H1N1 influenza A virus infection.[/h] Kim EH[SUP]1,[/SUP][SUP]2[/SUP], Choi YK[SUP]3[/SUP], Kim CJ[SUP]4[/SUP], Sung MH[SUP]5[/SUP], Poo H[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The global outbreak of a novel swine-origin strain of the 2009 H1N1 influenza A virus and the sudden, worldwide increase in oseltamivir-resistant H1N1 influenza A viruses highlight the urgent need for novel antiviral therapy.
[h=4]METHODS:[/h] Here, we investigated the antiviral efficacy of poly-gamma glutamate (γ-PGA), a safe and edible biomaterial that is naturally synthesized by Bacillus subtilis, against A/Puerto Rico/8/1934 (PR8) and A/California/04/2009 (CA04) H1N1 influenza A virus infections in C57BL/6 mice.
[h=4]RESULTS:[/h] Intranasal administration of γ-PGA for 5 days post-infection improved survival, increased production of antiviral cytokines including interferon-beta (IFN-β) and interleukin-12 (IL-12), and enhanced activation of natural killer (NK) cells and influenza antigen-specific cytotoxic T lymphocytes (CTL) activity.
[h=4]CONCLUSIONS:[/h] These results suggest that γ-PGA protects mice against H1N1 influenza A virus by enhancing antiviral immune responses.
PMID: 26437715 [PubMed - in process] PMCID: PMC4595321 Free PMC Article