tetano
Editor, Senior Moderator
Open Vet J. 2018;8(3):347-350. doi: 10.4314/ovj.v8i3.16. Epub 2018 Sep 30.
[h=1]Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria.[/h] Oladipo EK[SUP]1,[/SUP][SUP]2[/SUP], Oloke JK[SUP]2[/SUP], Adeniji JA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.
[h=4]KEYWORDS:[/h] H5N1; Influenza; Intravenous pathogenicity; Nigeria; Ogbomoso
PMID: 30483460 PMCID: PMC6172407 DOI: 10.4314/ovj.v8i3.16
[h=1]Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria.[/h] Oladipo EK[SUP]1,[/SUP][SUP]2[/SUP], Oloke JK[SUP]2[/SUP], Adeniji JA[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.
[h=4]KEYWORDS:[/h] H5N1; Influenza; Intravenous pathogenicity; Nigeria; Ogbomoso
PMID: 30483460 PMCID: PMC6172407 DOI: 10.4314/ovj.v8i3.16