tetano
Editor, Senior Moderator
J Infect Dis. 2015 May 5. pii: jiv269. [Epub ahead of print]
[h=1]Investigation of an outbreak of variant influenza A (H3N2) virus associated with an agricultural fair - Ohio, August 2012.[/h] Greenbaum A[SUP]1[/SUP], Quinn C[SUP]2[/SUP], Bailer J[SUP]3[/SUP], Su S[SUP]4[/SUP], Havers F[SUP]1[/SUP], Durand LO[SUP]5[/SUP], Jiang V[SUP]4[/SUP], Page S[SUP]6[/SUP], Budd J[SUP]6[/SUP], Shaw M[SUP]4[/SUP], Biggerstaff M[SUP]4[/SUP], de Fijter S[SUP]6[/SUP], Smith K[SUP]6[/SUP], Reed C[SUP]4[/SUP], Epperson S[SUP]4[/SUP], Brammer L[SUP]4[/SUP], Feltz D[SUP]6[/SUP], Sohner K[SUP]6[/SUP], Ford J[SUP]6[/SUP], Jain S[SUP]4[/SUP], Gargiullo P[SUP]4[/SUP], Weiss E[SUP]7[/SUP], Burg P[SUP]3[/SUP], DiOrio M[SUP]6[/SUP], Fowler B[SUP]6[/SUP], Finelli L[SUP]4[/SUP], Jhung MA[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In 2012, one third of cases in a multi-state outbreak of variant influenza A(H3N2) virus [(H3N2)v] occurred in Ohio. We conducted an investigation of (H3N2)v cases associated with agricultural Fair A in Ohio.
[h=4]METHODS:[/h] We surveyed Fair A swine exhibitors and their household members. Confirmed cases had influenza-like illness (ILI) and a positive laboratory test for (H3N2)v virus and probable cases had ILI. We calculated attack rates. We determined risk factors for infection using multivariable log-binomial regression.
[h=4]RESULTS:[/h] We identified a total of 20 confirmed and 94 probable cases associated with Fair A. Among 114 cases, the median age was 10 years, there were no hospitalizations or deaths, and 85% had swine exposure. In the exhibitor household cohort of 359 persons (83 households), we identified 6 confirmed (2%) and 40 probable (11%) cases. Age <10 years was a significant risk factor (p<0.01) for illness. One instance of likely human-to-human transmission was identified.
[h=4]CONCLUSIONS:[/h] In this (H3N2)v outbreak, no evidence of sustained human-to-human (H3N2)v transmission was found. Our risk factor analysis contributed to the development of recommendations that those at increased risk of influenza complications, including children aged <5 years, avoid swine barns at fairs during the 2012 fair season.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 25948864 [PubMed - as supplied by publisher]
[h=1]Investigation of an outbreak of variant influenza A (H3N2) virus associated with an agricultural fair - Ohio, August 2012.[/h] Greenbaum A[SUP]1[/SUP], Quinn C[SUP]2[/SUP], Bailer J[SUP]3[/SUP], Su S[SUP]4[/SUP], Havers F[SUP]1[/SUP], Durand LO[SUP]5[/SUP], Jiang V[SUP]4[/SUP], Page S[SUP]6[/SUP], Budd J[SUP]6[/SUP], Shaw M[SUP]4[/SUP], Biggerstaff M[SUP]4[/SUP], de Fijter S[SUP]6[/SUP], Smith K[SUP]6[/SUP], Reed C[SUP]4[/SUP], Epperson S[SUP]4[/SUP], Brammer L[SUP]4[/SUP], Feltz D[SUP]6[/SUP], Sohner K[SUP]6[/SUP], Ford J[SUP]6[/SUP], Jain S[SUP]4[/SUP], Gargiullo P[SUP]4[/SUP], Weiss E[SUP]7[/SUP], Burg P[SUP]3[/SUP], DiOrio M[SUP]6[/SUP], Fowler B[SUP]6[/SUP], Finelli L[SUP]4[/SUP], Jhung MA[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In 2012, one third of cases in a multi-state outbreak of variant influenza A(H3N2) virus [(H3N2)v] occurred in Ohio. We conducted an investigation of (H3N2)v cases associated with agricultural Fair A in Ohio.
[h=4]METHODS:[/h] We surveyed Fair A swine exhibitors and their household members. Confirmed cases had influenza-like illness (ILI) and a positive laboratory test for (H3N2)v virus and probable cases had ILI. We calculated attack rates. We determined risk factors for infection using multivariable log-binomial regression.
[h=4]RESULTS:[/h] We identified a total of 20 confirmed and 94 probable cases associated with Fair A. Among 114 cases, the median age was 10 years, there were no hospitalizations or deaths, and 85% had swine exposure. In the exhibitor household cohort of 359 persons (83 households), we identified 6 confirmed (2%) and 40 probable (11%) cases. Age <10 years was a significant risk factor (p<0.01) for illness. One instance of likely human-to-human transmission was identified.
[h=4]CONCLUSIONS:[/h] In this (H3N2)v outbreak, no evidence of sustained human-to-human (H3N2)v transmission was found. Our risk factor analysis contributed to the development of recommendations that those at increased risk of influenza complications, including children aged <5 years, avoid swine barns at fairs during the 2012 fair season.
Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 25948864 [PubMed - as supplied by publisher]