tetano
Editor, Senior Moderator
Clin Infect Dis. 2015 Nov 18. pii: civ957. [Epub ahead of print]
[h=1]Investing in Immunity: Pre-pandemic immunization to combat future influenza pandemics.[/h] Goodman JL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We are unlikely, with current technologies, to have sufficient pandemic influenza vaccine ready in time to impact the first wave of the next pandemic. Emerging data show that prior immunization with an immunologically distinct hemagglutinin of the same subtype offers the potential to "prime" recipients for rapid protection with a booster dose, years later, of a vaccine then manufactured to match the pandemic strain. This paper proposes making pre-pandemic priming vaccine(s) available for voluntary use, particularly to those at high risk of early occupational exposure, such as first responders and health care workers, and to others maintaining critical infrastructure. In addition to providing faster protection and potentially reducing social disruption, being able, early in a pandemic, to immunize those who had received pre-pandemic vaccine with one dose of the pandemic vaccine, rather than the 2 doses typically required, would reduce the total doses of pandemic vaccine then needed, extending vaccine supplies.
Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 26585520 [PubMed - as supplied by publisher]
[h=1]Investing in Immunity: Pre-pandemic immunization to combat future influenza pandemics.[/h] Goodman JL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We are unlikely, with current technologies, to have sufficient pandemic influenza vaccine ready in time to impact the first wave of the next pandemic. Emerging data show that prior immunization with an immunologically distinct hemagglutinin of the same subtype offers the potential to "prime" recipients for rapid protection with a booster dose, years later, of a vaccine then manufactured to match the pandemic strain. This paper proposes making pre-pandemic priming vaccine(s) available for voluntary use, particularly to those at high risk of early occupational exposure, such as first responders and health care workers, and to others maintaining critical infrastructure. In addition to providing faster protection and potentially reducing social disruption, being able, early in a pandemic, to immunize those who had received pre-pandemic vaccine with one dose of the pandemic vaccine, rather than the 2 doses typically required, would reduce the total doses of pandemic vaccine then needed, extending vaccine supplies.
Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 26585520 [PubMed - as supplied by publisher]