tetano
Editor, Senior Moderator
Iran J Med Sci
. 2021 Nov;46(6):487-492.
doi: 10.30476/IJMS.2021.47835.
Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
Ramin Sami[SUP] 1 [/SUP], Mohammad-Reza Hajian[SUP] 1 [/SUP], Babak Amra[SUP] 2 [/SUP], Forogh Soltaninejad[SUP] 1 [/SUP], Marjan Mansourian[SUP] 3 [/SUP], Sam Mirfendereski[SUP] 4 [/SUP], Raheleh Sadegh[SUP] 5 [/SUP], Nilufar Khademi[SUP] 1 [/SUP], Soheila Jalali[SUP] 6 [/SUP], Nafiseh Shokri-Mashhadi[SUP] 7 [/SUP]
Affiliations
Abstract
The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission's medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24[SUP]th[/SUP] to April 12[SUP]th[/SUP], 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (P<0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients.
Keywords: COVID-19; Medical laboratory science; Mortality; Risk factors.
. 2021 Nov;46(6):487-492.
doi: 10.30476/IJMS.2021.47835.
Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report
Ramin Sami[SUP] 1 [/SUP], Mohammad-Reza Hajian[SUP] 1 [/SUP], Babak Amra[SUP] 2 [/SUP], Forogh Soltaninejad[SUP] 1 [/SUP], Marjan Mansourian[SUP] 3 [/SUP], Sam Mirfendereski[SUP] 4 [/SUP], Raheleh Sadegh[SUP] 5 [/SUP], Nilufar Khademi[SUP] 1 [/SUP], Soheila Jalali[SUP] 6 [/SUP], Nafiseh Shokri-Mashhadi[SUP] 7 [/SUP]
Affiliations
- PMID: 34840389
- PMCID: PMC8611225
- DOI: 10.30476/IJMS.2021.47835
Abstract
The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission's medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24[SUP]th[/SUP] to April 12[SUP]th[/SUP], 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (P<0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients.
Keywords: COVID-19; Medical laboratory science; Mortality; Risk factors.