tetano
Editor, Senior Moderator
iScience
. 2025 Feb 3;28(3):111949.
doi: 10.1016/j.isci.2025.111949. eCollection 2025 Mar 21. Coronavirus replicase epitopes induce cross-reactive CD8 T cell responses in SARS-CoV-2-naive people with HIV-1
Katja G Schmidt[SUP] 1 [/SUP], Paulina Geißler[SUP] 1 [/SUP], Ev-Marie Schuster[SUP] 2 [/SUP], Christine Schülein[SUP] 2 [/SUP], Ellen G Harrer[SUP] 1 [/SUP], Verena Schönau[SUP] 3 [/SUP], Markus Luber[SUP] 4 [/SUP], Bernd Spriewald[SUP] 4 5 [/SUP], Philipp Steininger[SUP] 6 [/SUP], Silke Bergmann[SUP] 1 [/SUP], Armin Ensser[SUP] 6 [/SUP], Kilian Schober[SUP] 2 5 [/SUP], Krystelle Nganou-Makamdop[SUP] 6 [/SUP], Thomas Harrer[SUP] 1 5 [/SUP]
Affiliations
Cross-reactive T cell immunity between common cold coronaviruses and SARS-CoV-2 may influence COVID-19 susceptibility. To identify cross-reactive CD8 T cell epitopes, we analyzed responses to 21 homologous SARS-CoV-2 replicase peptides in 177 people living with HIV (PLWH) on antiretroviral therapy, of which 133 did not have prior SARS-CoV-2 infection. Replicase peptides induced IFN-γ responses in 63% of the SARS-CoV-2-naïve individuals and in 73% of individuals with prior SARS-CoV-2-infection. We could define several cross-reactive epitopes, including the HLA-B∗35:03 restricted CoV-YL8, and characterized a CoV-YL8-specific T cell receptor cloned from a SARS-CoV-2 seronegative individual. Analysis of the association between HLA-I alleles and SARS-CoV-2 infections over a 16-months period revealed that in a cohort of 452 PLWH, HLA-B∗35:03 and C∗07 were underrepresented in the 55 persons with a history of SARS-CoV-2 infection while HLA-B∗35:01 and HLA-C∗04 were associated with a higher infection rate. Taken together, our study suggests an HLA-I-mediated effect of common cold coronaviruses on SARS-CoV-2 immunity.
Keywords: Health sciences; Immunology; Medical specialty; Medicine; Virology.
. 2025 Feb 3;28(3):111949.
doi: 10.1016/j.isci.2025.111949. eCollection 2025 Mar 21. Coronavirus replicase epitopes induce cross-reactive CD8 T cell responses in SARS-CoV-2-naive people with HIV-1
Katja G Schmidt[SUP] 1 [/SUP], Paulina Geißler[SUP] 1 [/SUP], Ev-Marie Schuster[SUP] 2 [/SUP], Christine Schülein[SUP] 2 [/SUP], Ellen G Harrer[SUP] 1 [/SUP], Verena Schönau[SUP] 3 [/SUP], Markus Luber[SUP] 4 [/SUP], Bernd Spriewald[SUP] 4 5 [/SUP], Philipp Steininger[SUP] 6 [/SUP], Silke Bergmann[SUP] 1 [/SUP], Armin Ensser[SUP] 6 [/SUP], Kilian Schober[SUP] 2 5 [/SUP], Krystelle Nganou-Makamdop[SUP] 6 [/SUP], Thomas Harrer[SUP] 1 5 [/SUP]
Affiliations
- PMID: 40034846
- PMCID: PMC11872457
- DOI: 10.1016/j.isci.2025.111949
Cross-reactive T cell immunity between common cold coronaviruses and SARS-CoV-2 may influence COVID-19 susceptibility. To identify cross-reactive CD8 T cell epitopes, we analyzed responses to 21 homologous SARS-CoV-2 replicase peptides in 177 people living with HIV (PLWH) on antiretroviral therapy, of which 133 did not have prior SARS-CoV-2 infection. Replicase peptides induced IFN-γ responses in 63% of the SARS-CoV-2-naïve individuals and in 73% of individuals with prior SARS-CoV-2-infection. We could define several cross-reactive epitopes, including the HLA-B∗35:03 restricted CoV-YL8, and characterized a CoV-YL8-specific T cell receptor cloned from a SARS-CoV-2 seronegative individual. Analysis of the association between HLA-I alleles and SARS-CoV-2 infections over a 16-months period revealed that in a cohort of 452 PLWH, HLA-B∗35:03 and C∗07 were underrepresented in the 55 persons with a history of SARS-CoV-2 infection while HLA-B∗35:01 and HLA-C∗04 were associated with a higher infection rate. Taken together, our study suggests an HLA-I-mediated effect of common cold coronaviruses on SARS-CoV-2 immunity.
Keywords: Health sciences; Immunology; Medical specialty; Medicine; Virology.