tetano
Editor, Senior Moderator
iScience
. 2022 Feb 22;103967.
doi: 10.1016/j.isci.2022.103967. Online ahead of print.
Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
Zhao Ni Wang[SUP] 1 [/SUP], Xiang Sheng Yang[SUP] 1 [/SUP], Jing Sun[SUP] 1 [/SUP], Jin Cun Zhao[SUP] 1 2 [/SUP], Nan Shan Zhong[SUP] 1 2 [/SUP], Xiao Xiao Tang[SUP] 1 2 [/SUP]
Affiliations
Abstract
The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.
Keywords: Dynamics; Lung host response; Mouse model; Multi-omics analysis; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2022 Feb 22;103967.
doi: 10.1016/j.isci.2022.103967. Online ahead of print.
Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
Zhao Ni Wang[SUP] 1 [/SUP], Xiang Sheng Yang[SUP] 1 [/SUP], Jing Sun[SUP] 1 [/SUP], Jin Cun Zhao[SUP] 1 2 [/SUP], Nan Shan Zhong[SUP] 1 2 [/SUP], Xiao Xiao Tang[SUP] 1 2 [/SUP]
Affiliations
- PMID: 35224468
- PMCID: PMC8863311
- DOI: 10.1016/j.isci.2022.103967
Abstract
The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.
Keywords: Dynamics; Lung host response; Mouse model; Multi-omics analysis; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).