tetano
Editor, Senior Moderator
iScience
. 2024 Jul 17;27(8):110525.
doi: 10.1016/j.isci.2024.110525. eCollection 2024 Aug 16. Pandemic-associated pernio harbors footprints of an abortive SARS-CoV-2 infection
Lisa M Arkin[SUP] 1 [/SUP], Ana C Costa-da-Silva[SUP] 2 [/SUP], Justin Frere[SUP] 3 [/SUP], Ashley Ng[SUP] 1 [/SUP], Rubina Sharma[SUP] 2 [/SUP], John J Moon[SUP] 1 [/SUP], Hailey E Bussan[SUP] 4 [/SUP], Clara H Kim[SUP] 2 [/SUP], Ayesha Javaid[SUP] 2 [/SUP], Olivia R Steidl[SUP] 5 [/SUP], Ahmad Yatim[SUP] 6 7 [/SUP], Fanny Saidoune[SUP] 7 [/SUP], Michel Gilliet[SUP] 7 [/SUP], Joe T Nguyen[SUP] 2 [/SUP], Aman Nihal[SUP] 1 [/SUP], George Luong[SUP] 1 [/SUP], Meaghan Kenfield[SUP] 1 [/SUP], Lucia Carrau[SUP] 3 [/SUP], Jennifer M Tran[SUP] 1 [/SUP], Molly A Hinshaw[SUP] 1 [/SUP], Erin G Brooks[SUP] 4 [/SUP], Jose M Ayuso[SUP] 1 [/SUP], David H O'Connor[SUP] 4 [/SUP], Jean-Laurent Casanova[SUP] 6 8 9 10 11 [/SUP], Edward W Cowen[SUP] 12 [/SUP], Beth A Drolet[SUP] 1 [/SUP], Anne Marie Singh[SUP] 5 [/SUP], Benjamin tenOever[SUP] 3 [/SUP], Jacqueline W Mays[SUP] 2 [/SUP]
Affiliations
Elevated pernio incidence was observed during the COVID-19 pandemic. This prospective study enrolled subjects with pandemic-associated pernio in Wisconsin and Switzerland. Because pernio is a cutaneous manifestation of the interferonopathies, and type I interferon (IFN-I) immunity is critical to COVID-19 recovery, we tested the hypothesis that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated IFN-I signaling might underlie some pernio cases. Tissue-level IFN-I activity and plasmacytoid dendritic cell infiltrates were demonstrated in 100% of the Wisconsin cases. Across both cohorts, sparse SARS-CoV-2 RNA was captured in 25% (6/22) of biopsies, all with high inflammation. Affected patients lacked adaptive immunity to SARS-CoV-2. A hamster model of intranasal SARS-CoV-2 infection was used as a proof-of-principle experiment: RNA was detected in lungs and toes with IFN-I activity at both the sites, while replicating virus was found only in the lung. These data support a viral trigger for some pernio cases, where sustained local IFN-I activity can be triggered in the absence of seroconversion.
Keywords: Cell biology; Immune response; Immunology.
. 2024 Jul 17;27(8):110525.
doi: 10.1016/j.isci.2024.110525. eCollection 2024 Aug 16. Pandemic-associated pernio harbors footprints of an abortive SARS-CoV-2 infection
Lisa M Arkin[SUP] 1 [/SUP], Ana C Costa-da-Silva[SUP] 2 [/SUP], Justin Frere[SUP] 3 [/SUP], Ashley Ng[SUP] 1 [/SUP], Rubina Sharma[SUP] 2 [/SUP], John J Moon[SUP] 1 [/SUP], Hailey E Bussan[SUP] 4 [/SUP], Clara H Kim[SUP] 2 [/SUP], Ayesha Javaid[SUP] 2 [/SUP], Olivia R Steidl[SUP] 5 [/SUP], Ahmad Yatim[SUP] 6 7 [/SUP], Fanny Saidoune[SUP] 7 [/SUP], Michel Gilliet[SUP] 7 [/SUP], Joe T Nguyen[SUP] 2 [/SUP], Aman Nihal[SUP] 1 [/SUP], George Luong[SUP] 1 [/SUP], Meaghan Kenfield[SUP] 1 [/SUP], Lucia Carrau[SUP] 3 [/SUP], Jennifer M Tran[SUP] 1 [/SUP], Molly A Hinshaw[SUP] 1 [/SUP], Erin G Brooks[SUP] 4 [/SUP], Jose M Ayuso[SUP] 1 [/SUP], David H O'Connor[SUP] 4 [/SUP], Jean-Laurent Casanova[SUP] 6 8 9 10 11 [/SUP], Edward W Cowen[SUP] 12 [/SUP], Beth A Drolet[SUP] 1 [/SUP], Anne Marie Singh[SUP] 5 [/SUP], Benjamin tenOever[SUP] 3 [/SUP], Jacqueline W Mays[SUP] 2 [/SUP]
Affiliations
- PMID: 39156641
- PMCID: PMC11326933
- DOI: 10.1016/j.isci.2024.110525
Elevated pernio incidence was observed during the COVID-19 pandemic. This prospective study enrolled subjects with pandemic-associated pernio in Wisconsin and Switzerland. Because pernio is a cutaneous manifestation of the interferonopathies, and type I interferon (IFN-I) immunity is critical to COVID-19 recovery, we tested the hypothesis that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated IFN-I signaling might underlie some pernio cases. Tissue-level IFN-I activity and plasmacytoid dendritic cell infiltrates were demonstrated in 100% of the Wisconsin cases. Across both cohorts, sparse SARS-CoV-2 RNA was captured in 25% (6/22) of biopsies, all with high inflammation. Affected patients lacked adaptive immunity to SARS-CoV-2. A hamster model of intranasal SARS-CoV-2 infection was used as a proof-of-principle experiment: RNA was detected in lungs and toes with IFN-I activity at both the sites, while replicating virus was found only in the lung. These data support a viral trigger for some pernio cases, where sustained local IFN-I activity can be triggered in the absence of seroconversion.
Keywords: Cell biology; Immune response; Immunology.