tetano
Editor, Senior Moderator
iScience
. 2022 Aug 17;104959.
doi: 10.1016/j.isci.2022.104959. Online ahead of print.
SARS-CoV-2 specific CD4+ T cell longevity correlates with Th17-like phenotype
Kazutaka Terahara[SUP] 1 [/SUP], Takashi Sato[SUP] 2 [/SUP], Yu Adachi[SUP] 1 [/SUP], Keisuke Tonouchi[SUP] 1 3 [/SUP], Taishi Onodera[SUP] 1 [/SUP], Saya Moriyama[SUP] 1 [/SUP], Lin Sun[SUP] 1 [/SUP], Tomohiro Takano[SUP] 1 [/SUP], Ayae Nishiyama[SUP] 1 [/SUP], Ai Kawana-Tachikawa[SUP] 4 [/SUP], Tetsuro Matano[SUP] 4 [/SUP], Takayuki Matsumura[SUP] 1 [/SUP], Masaharu Shinkai[SUP] 2 [/SUP], Masanori Isogawa[SUP] 1 [/SUP], Yoshimasa Takahashi[SUP] 1 [/SUP]
Affiliations
Abstract
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe COVID-19 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers, and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses.
Keywords: Chemokine receptors; Memory T cell; Severe acute respiratory syndrome coronavirus 2; T cell longevity.
. 2022 Aug 17;104959.
doi: 10.1016/j.isci.2022.104959. Online ahead of print.
SARS-CoV-2 specific CD4+ T cell longevity correlates with Th17-like phenotype
Kazutaka Terahara[SUP] 1 [/SUP], Takashi Sato[SUP] 2 [/SUP], Yu Adachi[SUP] 1 [/SUP], Keisuke Tonouchi[SUP] 1 3 [/SUP], Taishi Onodera[SUP] 1 [/SUP], Saya Moriyama[SUP] 1 [/SUP], Lin Sun[SUP] 1 [/SUP], Tomohiro Takano[SUP] 1 [/SUP], Ayae Nishiyama[SUP] 1 [/SUP], Ai Kawana-Tachikawa[SUP] 4 [/SUP], Tetsuro Matano[SUP] 4 [/SUP], Takayuki Matsumura[SUP] 1 [/SUP], Masaharu Shinkai[SUP] 2 [/SUP], Masanori Isogawa[SUP] 1 [/SUP], Yoshimasa Takahashi[SUP] 1 [/SUP]
Affiliations
- PMID: 35992306
- PMCID: PMC9384329
- DOI: 10.1016/j.isci.2022.104959
Abstract
Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe COVID-19 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers, and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses.
Keywords: Chemokine receptors; Memory T cell; Severe acute respiratory syndrome coronavirus 2; T cell longevity.