Italy - H1N1, the ministry: a sporadic case of mutation in Italy

[Giuseppe]

H1N1, the ministry: a sporadic case of mutation in Italy

[Source: il Manifesto (LINK). Edited. Warning: Google Machine Translation.]

10:18 30/11

H1N1, the ministry: a case of mutation in Italy, sporadic case

MILAN (Reuters)


After the recent incidents in France and Norway, also in Italy there was a case of mutation of the H1N1 influenza virus - a patient with severe pneumonia, then settled - but the Ministry of Health says that the mutation in our country " sporadic "and" does not seem at this stage in the process of diffusion.

Last week the French authorities reported that two people died as a result of a mutation of the virus similar to a place in Norway, indicating that the phenomenon was found in two patients without any connection between them and hospitalized in two different cities.

"The mutation has been found so far in only one patient, a severe form of pneumonia resolved following treatment with ECMO performed in intensive care. None of the other patients examined, including those with serious or life-threatening events, showed that mutation "says the ministry in a statement, referring to data Superior Institute of Health.

The Italian data - continues the statement - confirmed that the mutation in question is not to be currently predominant in cases of serious or deadly new flu. The same mutation has a sporadic and does not seem at this stage in the process of diffusion.

The ministry also stated that the mutation does not impair the effectiveness of the vaccine or treatment with antiviral drugs.

"In this respect it is recalled that, according to data from the Higher Institute of Health on over 160 patients analyzed so far, has found a single case of resistance to oseltamivir. The resistance has been caused by prolonged treatment of a patient with severe pre-existing conditions and has remained isolated, not having responded to episodes of transmission of the resistant strain, "the statement said the ministry.

So far the virus has caused Italy 95 victims, with Campania, with 27 deaths, which remains the region where so far the highest number of deaths.

At 22 November, approximately 494,915 people were vaccinated, and vaccine doses delivered almost four million.

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THE MANIFESTO

 

[Giuseppe]

Re: Italy - H1N1, the ministry: a sporadic case of mutation in Italy

Pandemic Influenza H1N1 2009, the virus has mutated even in Italy

[Source: RomagnaOggi, LINK, EDITED. Warning: Google Machine Translation.]

November 30, 2009 - 10.25 (Last Update: 30 November 2009)
ROME



This was confirmed by the Ministry of Welfare.

The mutation was found so far in only one patient, a severe form of pneumonia resolved following treatment with ECMO, an apparatus for extracorporeal membrane oxygenation of the blood, performed in intensive care.

None of the other patients examined, including those with serious or life-threatening events, presented mutations.

Currently, the mutation is not dominant in cases of serious or deadly new flu. Moreover, the same mutation has a sporadic and does not seem at this stage in the process of diffusion.

"This mutation - has assured the ministry - does not impair the effectiveness of the vaccine nor treatment with antiviral drugs."

According to data from the ISS, on over 160 patients analyzed so far, has found a single case of resistance to oseltamivir, the antiviral drug used to counter the new influence.

"This resistance - said prosecutor - has been caused by prolonged treatment of a patient with severe pre-existing conditions and has remained isolated, not having responded to incidents of transmission of the resistant strain."

In Europe the virus mutations have occurred in Norway and France.
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[Giuseppe]

Re: Italy - H1N1, the ministry: a sporadic case of mutation in Italy

Influenza A, "The mutation of the virus does not change the effectiveness of the vaccine"

[Source: La Stampa (LINK), EDITED. Warning: Google Machine Translation.]

30/11/2009 (10:8)

Influenza A, "The mutation of the virus does not change the effectiveness of the vaccine"

Welfare Minister has announced the appearance of a first case of a patient who contracted the virus mutated in Italy


First case of mutation in Italy.

The Ministry of Welfare is reassuring: it is sporadic possibility

ROME


Italy has been identified in the first case of new mutation of the influenza A/H1N1 virus.

This was announced by the Ministry of Welfare, explaining that after reports of the Norwegian health authorities' the Higher Institute of Health has reassessed the sequences of more than 100 strains identified by as many patients diagnosed in recent months in various regions italiane.La mutation was found so far in only one patient suffering from a severe form of pneumonia resolved following treatment with ECMO performed in intensive care. None of the other patients examined, including those with serious or life-threatening manifestations, showed that mutation.

The mutation, however, emphasizes the ministry "does not impair the effectiveness of the vaccine or treatment with antiviral drugs. In this respect - he added - please note that, according to data from the Higher Institute of Health on over 160 patients analyzed so far, has found a single case of resistance to oseltamivir. This resistance has been caused by prolonged treatment of a patient with severe pre-existing conditions and has remained isolated, not having responded to incidents of transmission of the resistant strain. "

The Italian data, said the ministry, "confirmed that the mutation in question is not to be currently predominant in cases of serious or deadly new flu in addition, the same mutation has a sporadic and does not seem at this stage in the process of dissemination ' .

About a week ago, remembers the department, the Norwegian health authorities have reported the identification of a single mutation haemagglutinin (viral protein surface) of the new flu virus H1N1, which is to change a single amino acid (a glycine instead of an aspartic acid), in some patients with severe pneumonia.

Sporadic cases of the same mutation have been reported since April, in several countries around the world both in patients with severe pneumonia and patients with benign course of disease. The mutation did not even bother paediatricians, who just yesterday, the 65th national conference in Padua, had discussed the possibility of a mutation.

"No warning - explained Pier Angelo Tovo, Coordinator of the technique enabled the emergence A1 influenza H1N1 cases detected in Sweden and France to the influence of mutation of the virus. And no alarm even if some event were to occur then Italia.Resta unchanged - underlined - a preventive strategy based on vaccination, for now limited to those children at risk and then, in the next step planned by the ministry, extended to the entire pediatric population . The data in our possession, the vaccine currently used should in fact be protected even against viral mutations that currently exist, moreover, are not clinically more dangerous in the original virus.
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[Tonka]

Re: Italy - H1N1, the ministry: a sporadic case of mutation in Italy

http://www.milenio.com/node/331486

Mutation of the H1N1 virus confirmed in Italy
The mutation has been detected in samples from an individual patient provenienets and "does not affect the effectiveness of the vaccine or effective antiviral drug therapy," he said in a statement.

Mon, 30/11/2009 - 04:49
Rome .- A mutation of the H1N1 influenza virus has been recorded in Italy and other European countries, said the Ministry of Health.

The mutation has been detected in samples from an individual patient provenienets and "does not affect the effectiveness of the vaccine or effective antiviral drug therapy," he said in a statement.

Last week the Norwegian health authorities confirmed the identification of a mutation of the hemagglutinin, a surface protein of the H1N1 virus, consisting of an amino acid change in some critically ill patients with pneumonia.

"Sporadic cases of the same mutation have been reported since last April in several countries worldwide, both in patients with severe pneumonia, as in patients with mild effects of the disease," he added.

Following these reports, the Higher Institute of the Italian Health reviewed the sequences of more than 100 viral strains identified in as many patients diagnosed in recent months throughout the country.

"The mutation has been detected so far in a single patient, sick with a severe form of pneumonia, cured after ECMO therapy (known as machine saves lungs)," he said.

He insisted that no other patient had such a mutation which, he said, is sporadic and does not seem to phase diffusion.

He added that according to data from the Higher Institute of Health, some of the 160 patients tested was found a single case of a person resistant to oseltamivir, the antiviral medicine used against the new flu.

AH1N1 So far the virus has caused 95 deaths in Italy, of which 27 have died in suer?a Campania region, which has recorded more cases of the disease.

Notimex