tetano
Editor, Senior Moderator
J Allergy Clin Immunol
. 2020 Aug 15;S0091-6749(20)31136-2.
doi: 10.1016/j.jaci.2020.08.008. Online ahead of print.
Allergic disorders and susceptibility to and severity of COVID-19: a nationwide cohort study
Jee Myung Yang[SUP] 1 [/SUP], Hyun Yong Koh[SUP] 2 [/SUP], Sung Yong Moon[SUP] 3 [/SUP], In Kyung Yoo[SUP] 4 [/SUP], Eun Kyo Ha[SUP] 5 [/SUP], Seulgi You[SUP] 6 [/SUP], So Young Kim[SUP] 7 [/SUP], Dong Keon Yon[SUP] 8 [/SUP], Seung Won Lee[SUP] 9 [/SUP]
Affiliations
Abstract
Background: There is inconclusive and controversial evidence of the association between allergic diseases and the risk of adverse clinical outcomes of the coronavirus disease (COVID-19).
Objective: To determine the association of allergic disorders with the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and with clinical outcomes of COVID-19 (admission to intensive care unit, administration of invasive ventilation, and death).
Methods: A propensity-score-matched nationwide cohort study was performed in South Korea. Data obtained from the Health Insurance Review & Assessment Service of Korea from all adult patients (age >20 years) who were tested for SARS-CoV-2 in South Korea between January 1, 2020 and May 15, 2020 were analyzed. The association of SARS-CoV-2 test positivity and allergic diseases in the entire cohort (n=219,959) and the difference of clinical outcomes of COVID-19 were evaluated in patients with allergic diseases and SARS-CoV-2 positivity (n=7340).
Results: In the entire cohort, patients who underwent SARS-CoV-2 testing were evaluated to ascertain whether asthma and allergic rhinitis were associated with an increased likelihood of SARS-CoV-2 test positivity. After propensity score matching, we found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 positivity. Patients with non-allergic asthma had a greater risk of SARS-CoV-2 test positivity and worse clinical outcomes of COVID-19 than patients with allergic asthma.
Conclusion: In a Korean nationwide cohort, allergic rhinitis and asthma, especially non-allergic asthma, confers a greater risk of susceptibility to SARS-CoV-2 infection and severe clinical outcomes of COVID-19.
Keywords: COVID-19; allergic rhinitis; asthma; atopic dermatitis.
. 2020 Aug 15;S0091-6749(20)31136-2.
doi: 10.1016/j.jaci.2020.08.008. Online ahead of print.
Allergic disorders and susceptibility to and severity of COVID-19: a nationwide cohort study
Jee Myung Yang[SUP] 1 [/SUP], Hyun Yong Koh[SUP] 2 [/SUP], Sung Yong Moon[SUP] 3 [/SUP], In Kyung Yoo[SUP] 4 [/SUP], Eun Kyo Ha[SUP] 5 [/SUP], Seulgi You[SUP] 6 [/SUP], So Young Kim[SUP] 7 [/SUP], Dong Keon Yon[SUP] 8 [/SUP], Seung Won Lee[SUP] 9 [/SUP]
Affiliations
- PMID: 32810517
- DOI: 10.1016/j.jaci.2020.08.008
Abstract
Background: There is inconclusive and controversial evidence of the association between allergic diseases and the risk of adverse clinical outcomes of the coronavirus disease (COVID-19).
Objective: To determine the association of allergic disorders with the likelihood of a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result and with clinical outcomes of COVID-19 (admission to intensive care unit, administration of invasive ventilation, and death).
Methods: A propensity-score-matched nationwide cohort study was performed in South Korea. Data obtained from the Health Insurance Review & Assessment Service of Korea from all adult patients (age >20 years) who were tested for SARS-CoV-2 in South Korea between January 1, 2020 and May 15, 2020 were analyzed. The association of SARS-CoV-2 test positivity and allergic diseases in the entire cohort (n=219,959) and the difference of clinical outcomes of COVID-19 were evaluated in patients with allergic diseases and SARS-CoV-2 positivity (n=7340).
Results: In the entire cohort, patients who underwent SARS-CoV-2 testing were evaluated to ascertain whether asthma and allergic rhinitis were associated with an increased likelihood of SARS-CoV-2 test positivity. After propensity score matching, we found that asthma and allergic rhinitis were associated with worse clinical outcomes of COVID-19 in patients with SARS-CoV-2 positivity. Patients with non-allergic asthma had a greater risk of SARS-CoV-2 test positivity and worse clinical outcomes of COVID-19 than patients with allergic asthma.
Conclusion: In a Korean nationwide cohort, allergic rhinitis and asthma, especially non-allergic asthma, confers a greater risk of susceptibility to SARS-CoV-2 infection and severe clinical outcomes of COVID-19.
Keywords: COVID-19; allergic rhinitis; asthma; atopic dermatitis.