tetano
Editor, Senior Moderator
J Allergy Clin Immunol
. 2024 Mar 18:S0091-6749(24)00129-5.
doi: 10.1016/j.jaci.2024.01.025. Online ahead of print. Autoimmune adverse event following COVID-19 vaccination in Seoul, South Korea
Hong Jin Kim[SUP] 1 [/SUP], Min-Ho Kim[SUP] 2 [/SUP], Seong Jun Park[SUP] 3 [/SUP], Myeong Geun Choi[SUP] 3 [/SUP], Eun Mi Chun[SUP] 4 [/SUP]
Affiliations
Background: There is growing evidence that the coronavirus disease 2019 (COVID-19) vaccination can affect the regulation of the immune system, leading to the development of autoimmune diseases. However, the autoimmune adverse events (AEs) after COVID-19 vaccination remain largely unclear.
Objective: We sought to investigate the autoimmune AEs after COVID-19 vaccination from a population-based cohort in South Korea.
Methods: A total of 4,203,887 participants, representing 50% of the population residing in Seoul, were recruited from the National Health Insurance Service database and then divided into 2 groups on the basis of COVID-19 vaccination. The cumulative incidence, hazard ratios (HRs), and 95% CIs of autoimmune AEs were assessed following COVID-19 vaccination.
Results: The incidence of vitiligo has been observed to be significantly higher in the vaccination group compared with the no vaccination group. The cumulative incidence of vitiligo began to show a significant difference starting 2 weeks after vaccination, and it reached 2.2% in the vaccination group and 0.6% in the no vaccination group by 3 months after COVID-19 vaccination. Vitiligo (HR, 2.714; 95% CI, 1.777-4.146) was an increased risk among autoimmune AEs. Furthermore, the risk of vitiligo was the highest for heterologous vaccination (HR, 3.890; 95% CI, 2.303-6.573) compared with using cDNA vaccine (HR, 2.861; 95% CI, 1.838-4.453) or mRNA vaccine (HR, 2.475; 95% CI, 1.607-3.813).
Conclusions: Vitiligo as an autoimmune AE was noted to be substantially higher in the COVID-19-vaccinated group compared with the controls. Therefore, the occurrence of vitiligo could be considered as one of the significant AEs post-COVID-19 vaccination.
Keywords: COVID-19; autoimmune adverse events; complications; vaccination; vitiligo.
. 2024 Mar 18:S0091-6749(24)00129-5.
doi: 10.1016/j.jaci.2024.01.025. Online ahead of print. Autoimmune adverse event following COVID-19 vaccination in Seoul, South Korea
Hong Jin Kim[SUP] 1 [/SUP], Min-Ho Kim[SUP] 2 [/SUP], Seong Jun Park[SUP] 3 [/SUP], Myeong Geun Choi[SUP] 3 [/SUP], Eun Mi Chun[SUP] 4 [/SUP]
Affiliations
- PMID: 38520423
- DOI: 10.1016/j.jaci.2024.01.025
Background: There is growing evidence that the coronavirus disease 2019 (COVID-19) vaccination can affect the regulation of the immune system, leading to the development of autoimmune diseases. However, the autoimmune adverse events (AEs) after COVID-19 vaccination remain largely unclear.
Objective: We sought to investigate the autoimmune AEs after COVID-19 vaccination from a population-based cohort in South Korea.
Methods: A total of 4,203,887 participants, representing 50% of the population residing in Seoul, were recruited from the National Health Insurance Service database and then divided into 2 groups on the basis of COVID-19 vaccination. The cumulative incidence, hazard ratios (HRs), and 95% CIs of autoimmune AEs were assessed following COVID-19 vaccination.
Results: The incidence of vitiligo has been observed to be significantly higher in the vaccination group compared with the no vaccination group. The cumulative incidence of vitiligo began to show a significant difference starting 2 weeks after vaccination, and it reached 2.2% in the vaccination group and 0.6% in the no vaccination group by 3 months after COVID-19 vaccination. Vitiligo (HR, 2.714; 95% CI, 1.777-4.146) was an increased risk among autoimmune AEs. Furthermore, the risk of vitiligo was the highest for heterologous vaccination (HR, 3.890; 95% CI, 2.303-6.573) compared with using cDNA vaccine (HR, 2.861; 95% CI, 1.838-4.453) or mRNA vaccine (HR, 2.475; 95% CI, 1.607-3.813).
Conclusions: Vitiligo as an autoimmune AE was noted to be substantially higher in the COVID-19-vaccinated group compared with the controls. Therefore, the occurrence of vitiligo could be considered as one of the significant AEs post-COVID-19 vaccination.
Keywords: COVID-19; autoimmune adverse events; complications; vaccination; vitiligo.