tetano
Editor, Senior Moderator
J Alzheimers Dis
. 2022 Apr 11.
doi: 10.3233/JAD-215506. Online ahead of print.
Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints
Daniela Andriuta[SUP] 1 2 [/SUP], Cherifa Si-Ahmed[SUP] 1 [/SUP], Martine Roussel[SUP] 1 2 [/SUP], Jean-Marc Constans[SUP] 3 [/SUP], Malek Makki[SUP] 2 [/SUP], Ardalan Aarabi[SUP] 2 [/SUP], Damien Basille[SUP] 4 [/SUP], Claire Andrejak[SUP] 4 [/SUP], Olivier Godefroy[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants.
Objective: To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary objectives were to assess their clinical and MRI determinants.
Methods: We included 46 patients with a post-acute COVID-19 cognitive complaint referred to the Amiens University Hospital Memory Center. They underwent a neuropsychological assessment and 36 had cerebral MRI. The G3 overall summary score was the sum of the mean z scores for the executive function, language, and action speed domains. Neuropsychological profiles were compared in a general linear model. Clinical determinants were analyzed by stepwise linear regression. White matter hyperintensities (WMH) masks were analyzed using parcel-based WMH symptom mapping to identify the locations of WMHs associated with cognitive performance.
Results: Repeated ANOVA showed a group effect (p = 0.0001) due to overall lower performance for patients and a domain effect (p = 0.0001) due to a lower (p = 0.007) action speed score. The G3 overall summary score was significantly associated with solely the requirement for oxygen (R2 = 0.319, p = 0.031). WHMs were associated with the G3 overall summary score in the following structures, all right-sided (p < 0.01): superior frontal region, postcentral region, cingulum, cortico-spinal tract, inferior longitudinal fasciculus, internal capsule, and posterior segment of the arcuate fasciculus.
Conclusion: Post-acute COVID-19 patients with cognitive complaints had NCD, with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH structure pattern.
Keywords: COVID-19; neurocognitive disorders; post-acute COVID-19; white matter hyperintensities.
. 2022 Apr 11.
doi: 10.3233/JAD-215506. Online ahead of print.
Clinical and Imaging Determinants of Neurocognitive Disorders in Post-Acute COVID-19 Patients with Cognitive Complaints
Daniela Andriuta[SUP] 1 2 [/SUP], Cherifa Si-Ahmed[SUP] 1 [/SUP], Martine Roussel[SUP] 1 2 [/SUP], Jean-Marc Constans[SUP] 3 [/SUP], Malek Makki[SUP] 2 [/SUP], Ardalan Aarabi[SUP] 2 [/SUP], Damien Basille[SUP] 4 [/SUP], Claire Andrejak[SUP] 4 [/SUP], Olivier Godefroy[SUP] 1 [/SUP]
Affiliations
- PMID: 35431242
- DOI: 10.3233/JAD-215506
Abstract
Background: Neurocognitive disorders (NCDs) are a part of the post-acute coronavirus disease (COVID-19) syndrome. No study has specifically evaluated NCDs in post-acute COVID-19 patients with cognitive complaints or their MRI determinants.
Objective: To characterize NCDs in post-acute COVID-19 patients with cognitive complaints. The secondary objectives were to assess their clinical and MRI determinants.
Methods: We included 46 patients with a post-acute COVID-19 cognitive complaint referred to the Amiens University Hospital Memory Center. They underwent a neuropsychological assessment and 36 had cerebral MRI. The G3 overall summary score was the sum of the mean z scores for the executive function, language, and action speed domains. Neuropsychological profiles were compared in a general linear model. Clinical determinants were analyzed by stepwise linear regression. White matter hyperintensities (WMH) masks were analyzed using parcel-based WMH symptom mapping to identify the locations of WMHs associated with cognitive performance.
Results: Repeated ANOVA showed a group effect (p = 0.0001) due to overall lower performance for patients and a domain effect (p = 0.0001) due to a lower (p = 0.007) action speed score. The G3 overall summary score was significantly associated with solely the requirement for oxygen (R2 = 0.319, p = 0.031). WHMs were associated with the G3 overall summary score in the following structures, all right-sided (p < 0.01): superior frontal region, postcentral region, cingulum, cortico-spinal tract, inferior longitudinal fasciculus, internal capsule, and posterior segment of the arcuate fasciculus.
Conclusion: Post-acute COVID-19 patients with cognitive complaints had NCD, with prominent action slowing, significantly associated with the acute phase oxygen requirement and a right-sided WMH structure pattern.
Keywords: COVID-19; neurocognitive disorders; post-acute COVID-19; white matter hyperintensities.