tetano
Editor, Senior Moderator
J Am Chem Soc
. 2023 Dec 8.
doi: 10.1021/jacs.3c12678. Online ahead of print. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells
Xiaohong Sang[SUP] 1 [/SUP], Juan Wang[SUP] 2 [/SUP], Jiao Zhou[SUP] 1 [/SUP], Yan Xu[SUP] 1 [/SUP], Jing An[SUP] 3 [/SUP], Arieh Warshel[SUP] 4 [/SUP], Ziwei Huang[SUP] 1 2 3 [/SUP]
Affiliations
SARS-CoV-2 is the virus that causes the global pandemic of COVID-19. The main protease (M[SUP]pro[/SUP]) of SARS-CoV-2 is essential for viral infection and is one of the major therapeutic targets for COVID-19. Here, we report the design, synthesis, and biological characterization of a novel heterobifunctional small molecule that could effectively induce the degradation of SARS-CoV-2 M[SUP]pro[/SUP] and its drug-resistant mutants in HEK 293T cells, thus demonstrating a new alternative strategy for intervening with proteins important for this novel coronavirus.
. 2023 Dec 8.
doi: 10.1021/jacs.3c12678. Online ahead of print. A Chemical Strategy for the Degradation of the Main Protease of SARS-CoV-2 in Cells
Xiaohong Sang[SUP] 1 [/SUP], Juan Wang[SUP] 2 [/SUP], Jiao Zhou[SUP] 1 [/SUP], Yan Xu[SUP] 1 [/SUP], Jing An[SUP] 3 [/SUP], Arieh Warshel[SUP] 4 [/SUP], Ziwei Huang[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 38064654
- DOI: 10.1021/jacs.3c12678
SARS-CoV-2 is the virus that causes the global pandemic of COVID-19. The main protease (M[SUP]pro[/SUP]) of SARS-CoV-2 is essential for viral infection and is one of the major therapeutic targets for COVID-19. Here, we report the design, synthesis, and biological characterization of a novel heterobifunctional small molecule that could effectively induce the degradation of SARS-CoV-2 M[SUP]pro[/SUP] and its drug-resistant mutants in HEK 293T cells, thus demonstrating a new alternative strategy for intervening with proteins important for this novel coronavirus.