tetano
Editor, Senior Moderator
J Antimicrob Chemother
. 2021 Sep 23;76(Supplement_3):iii12-iii19.
doi: 10.1093/jac/dkab244.
SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study
Sweta Chekuri[SUP] 1 2 3 [/SUP], Wendy A Szymczak[SUP] 1 4 [/SUP], D Yitzchak Goldstein[SUP] 1 4 [/SUP], Priya Nori[SUP] 1 2 5 [/SUP], Rebecca Marrero Rolon[SUP] 1 4 [/SUP], Brian Spund[SUP] 1 2 3 [/SUP], Sumeet Singh-Tan[SUP] 1 2 3 [/SUP], Laurel Mohrmann[SUP] 1 2 3 [/SUP], Andrei Assa[SUP] 1 2 3 [/SUP], William N Southern[SUP] 1 2 3 [/SUP], Sarah W Baron[SUP] 1 2 3 [/SUP]
Affiliations
Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat.
Objectives: Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. SARS-CoV-2 positivity with an additional respiratory virus) was associated with more severe presentation and outcomes.
Methods: All patients with negative influenza/respiratory syncytial virus testing who underwent RPP testing within 7 days of a positive SARS-CoV-2 test at a large, academic medical centre in New York were examined. Patients positive for SARS-CoV-2 with a negative RPP were compared with patients positive for SARS-CoV-2 and positive for a virus by RPP in terms of biomarkers, oxygen requirements and severe COVID-19 outcome, as defined by mechanical ventilation or death within 30 days.
Results: Of the 306 SARS-CoV-2-positive patients with RPP testing, 14 (4.6%) were positive for a non-influenza virus (coinfected). Compared with the coinfected group, patients positive for SARS-CoV-2 with a negative RPP had higher inflammatory markers and were significantly more likely to be admitted (P = 0.01). Severe COVID-19 outcome occurred in 111 (36.3%) patients in the SARS-CoV-2-only group and 3 (21.4%) patients in the coinfected group (P = 0.24).
Conclusions: Patients infected with SARS-CoV-2 along with a non-influenza respiratory virus had less severe disease on presentation and were more likely to be admitted-but did not have more severe outcomes-than those infected with SARS-CoV-2 alone.
. 2021 Sep 23;76(Supplement_3):iii12-iii19.
doi: 10.1093/jac/dkab244.
SARS-CoV-2 coinfection with additional respiratory virus does not predict severe disease: a retrospective cohort study
Sweta Chekuri[SUP] 1 2 3 [/SUP], Wendy A Szymczak[SUP] 1 4 [/SUP], D Yitzchak Goldstein[SUP] 1 4 [/SUP], Priya Nori[SUP] 1 2 5 [/SUP], Rebecca Marrero Rolon[SUP] 1 4 [/SUP], Brian Spund[SUP] 1 2 3 [/SUP], Sumeet Singh-Tan[SUP] 1 2 3 [/SUP], Laurel Mohrmann[SUP] 1 2 3 [/SUP], Andrei Assa[SUP] 1 2 3 [/SUP], William N Southern[SUP] 1 2 3 [/SUP], Sarah W Baron[SUP] 1 2 3 [/SUP]
Affiliations
- PMID: 34555160
- DOI: 10.1093/jac/dkab244
Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) claimed over 4 million lives by July 2021 and continues to pose a serious public health threat.
Objectives: Our retrospective study utilized respiratory pathogen panel (RPP) results in patients with SARS-CoV-2 to determine if coinfection (i.e. SARS-CoV-2 positivity with an additional respiratory virus) was associated with more severe presentation and outcomes.
Methods: All patients with negative influenza/respiratory syncytial virus testing who underwent RPP testing within 7 days of a positive SARS-CoV-2 test at a large, academic medical centre in New York were examined. Patients positive for SARS-CoV-2 with a negative RPP were compared with patients positive for SARS-CoV-2 and positive for a virus by RPP in terms of biomarkers, oxygen requirements and severe COVID-19 outcome, as defined by mechanical ventilation or death within 30 days.
Results: Of the 306 SARS-CoV-2-positive patients with RPP testing, 14 (4.6%) were positive for a non-influenza virus (coinfected). Compared with the coinfected group, patients positive for SARS-CoV-2 with a negative RPP had higher inflammatory markers and were significantly more likely to be admitted (P = 0.01). Severe COVID-19 outcome occurred in 111 (36.3%) patients in the SARS-CoV-2-only group and 3 (21.4%) patients in the coinfected group (P = 0.24).
Conclusions: Patients infected with SARS-CoV-2 along with a non-influenza respiratory virus had less severe disease on presentation and were more likely to be admitted-but did not have more severe outcomes-than those infected with SARS-CoV-2 alone.