tetano
Editor, Senior Moderator
J Appl Genet
. 2022 Apr 9.
doi: 10.1007/s13353-022-00689-w. Online ahead of print.
The basis of mink susceptibility to SARS-CoV-2 infection
Avishak Barua[SUP] 1 [/SUP], Natalia Grot[SUP] 2 [/SUP], Andrzej Plawski[SUP] 3 4 [/SUP]
Affiliations
Abstract
Of all known airborne diseases in the twenty-first century, coronavirus disease 19 (COVID-19) has the highest infection and death rate. Over the past few decades, animal origin viral diseases, notably those of bats-linked, have increased many folds in humans with cross-species transmissions noted and the ongoing COVID-19 pandemic has emphasized the importance of understanding the evolution of natural hosts in response to viral pathogens. Cross-species transmissions are possible due to the possession of the angiotensin-converting enzyme 2 (ACE2) receptor in animals. ACE2 recognition by SARS-CoV-2 is a critical determinant of the host range, interspecies transmission, and viral pathogenesis. Thus, the phenomenon of breaking the cross-species barrier is mainly associated with mutations in the receptor-binding domain (RBD) of the spike (S) protein that interacts with ACE2. In this review, we raise the issue of cross-species transmission based on sequence alignment of S protein. Based on previous reports and our observations, we can conclude that the occurrence of one of two mutations D614G or Y453F is sufficient for infection of minks by SARS-CoV-2 from humans. Unfortunately, D614G is observed in the world's most common line of virus B.1.1.7 and the latest SARS-CoV-2 variants B.1.617.1, B.1.617.2, and B.1.617.3 too.
Keywords: Coronavirus; Cross-species infection; Minks; SARS-CoV-2; Spike protein.
. 2022 Apr 9.
doi: 10.1007/s13353-022-00689-w. Online ahead of print.
The basis of mink susceptibility to SARS-CoV-2 infection
Avishak Barua[SUP] 1 [/SUP], Natalia Grot[SUP] 2 [/SUP], Andrzej Plawski[SUP] 3 4 [/SUP]
Affiliations
- PMID: 35396646
- DOI: 10.1007/s13353-022-00689-w
Abstract
Of all known airborne diseases in the twenty-first century, coronavirus disease 19 (COVID-19) has the highest infection and death rate. Over the past few decades, animal origin viral diseases, notably those of bats-linked, have increased many folds in humans with cross-species transmissions noted and the ongoing COVID-19 pandemic has emphasized the importance of understanding the evolution of natural hosts in response to viral pathogens. Cross-species transmissions are possible due to the possession of the angiotensin-converting enzyme 2 (ACE2) receptor in animals. ACE2 recognition by SARS-CoV-2 is a critical determinant of the host range, interspecies transmission, and viral pathogenesis. Thus, the phenomenon of breaking the cross-species barrier is mainly associated with mutations in the receptor-binding domain (RBD) of the spike (S) protein that interacts with ACE2. In this review, we raise the issue of cross-species transmission based on sequence alignment of S protein. Based on previous reports and our observations, we can conclude that the occurrence of one of two mutations D614G or Y453F is sufficient for infection of minks by SARS-CoV-2 from humans. Unfortunately, D614G is observed in the world's most common line of virus B.1.1.7 and the latest SARS-CoV-2 variants B.1.617.1, B.1.617.2, and B.1.617.3 too.
Keywords: Coronavirus; Cross-species infection; Minks; SARS-CoV-2; Spike protein.