tetano
Editor, Senior Moderator
J Basic Clin Physiol Pharmacol
. 2021 Nov 26.
doi: 10.1515/jbcpp-2021-0083. Online ahead of print.
Perspectives into the possible effects of the B.1.1.7 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on spermatogenesis
Andrea M T Kallumadyil[SUP] 1 [/SUP], Tess McClenahan[SUP] 1 [/SUP], Samantha De Filippis[SUP] 1 [/SUP], Ananya Vungarala[SUP] 1 [/SUP], Nihal Satyadev[SUP] 1 [/SUP], Robert S Waters[SUP] 2 [/SUP], Anand L Kulkarni[SUP] 1 [/SUP]
Affiliations
Abstract
B.1.1.7 is a recently discovered variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with increased transmissibility. Recent findings indicate that this variant has a propensity to infect adolescents and children at higher rates than adults. The virus gains entry into various body cells utilizing angiotensin-converting enzyme 2 (ACE-2) and basigin (CD147) as receptors. The virus mainly affects type II pneumocytes of lungs, endothelial cells, enterocytes, and renal tubular cells. It is reported to affect testes, causing testicular pain, and producing histopathological changes, as observed in some autopsies. The B.1.1.7 variant can also affect various cells in the testes. This raises a major concern regarding the long-term effects of the viral infection on spermatogenesis and highlights the pressing need for a robust database of serum samples from infected male children.
Keywords: B.1.1.7; COVID-19; SARS-CoV-2; infertility; spermatogenesis; subfertility; testes; variant.
. 2021 Nov 26.
doi: 10.1515/jbcpp-2021-0083. Online ahead of print.
Perspectives into the possible effects of the B.1.1.7 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on spermatogenesis
Andrea M T Kallumadyil[SUP] 1 [/SUP], Tess McClenahan[SUP] 1 [/SUP], Samantha De Filippis[SUP] 1 [/SUP], Ananya Vungarala[SUP] 1 [/SUP], Nihal Satyadev[SUP] 1 [/SUP], Robert S Waters[SUP] 2 [/SUP], Anand L Kulkarni[SUP] 1 [/SUP]
Affiliations
- PMID: 34837491
- DOI: 10.1515/jbcpp-2021-0083
Abstract
B.1.1.7 is a recently discovered variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated with increased transmissibility. Recent findings indicate that this variant has a propensity to infect adolescents and children at higher rates than adults. The virus gains entry into various body cells utilizing angiotensin-converting enzyme 2 (ACE-2) and basigin (CD147) as receptors. The virus mainly affects type II pneumocytes of lungs, endothelial cells, enterocytes, and renal tubular cells. It is reported to affect testes, causing testicular pain, and producing histopathological changes, as observed in some autopsies. The B.1.1.7 variant can also affect various cells in the testes. This raises a major concern regarding the long-term effects of the viral infection on spermatogenesis and highlights the pressing need for a robust database of serum samples from infected male children.
Keywords: B.1.1.7; COVID-19; SARS-CoV-2; infertility; spermatogenesis; subfertility; testes; variant.