tetano
Editor, Senior Moderator
J Biol Rhythms
. 2021 Dec 4;7487304211059315.
doi: 10.1177/07487304211059315. Online ahead of print.
Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
Wei Wang[SUP] 1 [/SUP], Peter Balfe[SUP] 2 [/SUP], David W Eyre[SUP] 3 [/SUP], Sheila F Lumley[SUP] 2 4 [/SUP], Denise O'Donnell[SUP] 4 [/SUP], Fiona Warren[SUP] 4 [/SUP], Derrick W Crook[SUP] 2 4 5 [/SUP], Katie Jeffery[SUP] 4 6 [/SUP], Philippa C Matthews[SUP] 2 4 [/SUP], Elizabeth B Klerman[SUP] 7 [/SUP], Jane A McKeating[SUP] 2 8 [/SUP]
Affiliations
Abstract
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy.
Keywords: COVID-19; HCW; SARS-CoV-2; Spike antibody; time of day.
. 2021 Dec 4;7487304211059315.
doi: 10.1177/07487304211059315. Online ahead of print.
Time of Day of Vaccination Affects SARS-CoV-2 Antibody Responses in an Observational Study of Health Care Workers
Wei Wang[SUP] 1 [/SUP], Peter Balfe[SUP] 2 [/SUP], David W Eyre[SUP] 3 [/SUP], Sheila F Lumley[SUP] 2 4 [/SUP], Denise O'Donnell[SUP] 4 [/SUP], Fiona Warren[SUP] 4 [/SUP], Derrick W Crook[SUP] 2 4 5 [/SUP], Katie Jeffery[SUP] 4 6 [/SUP], Philippa C Matthews[SUP] 2 4 [/SUP], Elizabeth B Klerman[SUP] 7 [/SUP], Jane A McKeating[SUP] 2 8 [/SUP]
Affiliations
- PMID: 34866459
- DOI: 10.1177/07487304211059315
Abstract
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy.
Keywords: COVID-19; HCW; SARS-CoV-2; Spike antibody; time of day.