tetano
Editor, Senior Moderator
J Biomol Struct Dyn. 2020 May 13:1-13. doi: 10.1080/07391102.2020.1767211. [Epub ahead of print]
The expression level of angiotensin-converting enzyme 2 determine the severity of COVID-19: lung and heart tissue as targets.
Nejadi Babadaei MM[SUP]1[/SUP], Hasan A[SUP]2,[/SUP][SUP]3[/SUP], Haj Bloukh S[SUP]4[/SUP], Edis Z[SUP]5[/SUP], Sharifi M[SUP]6[/SUP], Kachooei E[SUP]7[/SUP], Falahati M[SUP]6[/SUP].
Author information
Abstract
Researchers have reported some useful information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to coronavirus disease 2019 (COVID-19). Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients in addition, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. The surface of host cells is covered by some receptors, known as ACE2, which mediates the binding and entry of CoV. After entering, the viral RNA interrupts the cell proliferation system to activate self-proliferation.However, having all the information about the prevalence of the SARS-COV-2, it is not still clear which factors determine the severity of lung and heart function impairment induced by COVID-19. A major step in exploring SARS-COV-2 pathogenesis is to determine the distribution of ACE2 proteins on tissue surface. In this review, the structure and origin of CoV, the role of ACE2 as a receptor of SARS-COV-2 on the surface of host cells, and the ACE2 distribution in different tissues with a focus on lung and cardiovascular system has been discussed. It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. In conclusion, this review may provide useful information to develop some strategies to end up with a worldwide COVID-19 pandemic.
KEYWORDS:
ACE2; COVID-19; Coronavirus; Heart; Lung; MERS; SARS; SARS-CoV-2
PMID:32397951DOI:10.1080/07391102.2020.1767211
The expression level of angiotensin-converting enzyme 2 determine the severity of COVID-19: lung and heart tissue as targets.
Nejadi Babadaei MM[SUP]1[/SUP], Hasan A[SUP]2,[/SUP][SUP]3[/SUP], Haj Bloukh S[SUP]4[/SUP], Edis Z[SUP]5[/SUP], Sharifi M[SUP]6[/SUP], Kachooei E[SUP]7[/SUP], Falahati M[SUP]6[/SUP].
Author information
Abstract
Researchers have reported some useful information about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to coronavirus disease 2019 (COVID-19). Several studies have been performed in order to develop antiviral drugs, from which a few have been prescribed to patients in addition, several diagnostic tests have been designed to accelerate the process of identifying and treating COVID-19. The surface of host cells is covered by some receptors, known as ACE2, which mediates the binding and entry of CoV. After entering, the viral RNA interrupts the cell proliferation system to activate self-proliferation.However, having all the information about the prevalence of the SARS-COV-2, it is not still clear which factors determine the severity of lung and heart function impairment induced by COVID-19. A major step in exploring SARS-COV-2 pathogenesis is to determine the distribution of ACE2 proteins on tissue surface. In this review, the structure and origin of CoV, the role of ACE2 as a receptor of SARS-COV-2 on the surface of host cells, and the ACE2 distribution in different tissues with a focus on lung and cardiovascular system has been discussed. It was also revealed that acute and chronic cardiovascular diseases (CVDs) may result in the clinical severity of COVID-19. In conclusion, this review may provide useful information to develop some strategies to end up with a worldwide COVID-19 pandemic.
KEYWORDS:
ACE2; COVID-19; Coronavirus; Heart; Lung; MERS; SARS; SARS-CoV-2
PMID:32397951DOI:10.1080/07391102.2020.1767211