tetano
Editor, Senior Moderator
J Cell Commun Signal
. 2021 Sep 6.
doi: 10.1007/s12079-021-00642-2. Online ahead of print.
A pathway map of signaling events triggered upon SARS-CoV infection
K T Shreya Parthasarathi[SUP] #[/SUP][SUP] 1 [/SUP], Nupur S Munjal[SUP] #[/SUP][SUP] 1 [/SUP], Gourav Dey[SUP] 1 [/SUP], Abhishek Kumar[SUP] 1 2 [/SUP], Akhilesh Pandey[SUP] 3 4 5 [/SUP], Lavanya Balakrishnan[SUP] 6 [/SUP], Jyoti Sharma[SUP] 7 8 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronaviruses (SARS-CoVs) caused worldwide epidemics over the past few decades. Extensive studies on various strains of coronaviruses provided a basic understanding of the pathogenesis of the disease. Presently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading a global pandemic with unprecedented challenges. This is the third coronavirus outbreak of this century. A signaling pathway map of signaling events induced by SARS-CoV infection is not yet available. In this study, we present a literature-annotated signaling pathway map of reactions induced by SARS-CoV infected cells. Multiple signaling modules were found to be orchestrated including PI3K-AKT, Ras-MAPK, JAK-STAT, Type 1 IFN and NFκB. The signaling pathway map of SARS-CoV consists of 110 molecules and 101 reactions mediated by SARS-CoV proteins. The pathway reaction data are available in various community standard data exchange formats including Systems Biology Graphical Notation (SBGN). The pathway map is publicly available through the GitHub repository and data in various formats can be freely downloadable.
Keywords: COVID-19; Differential expression; Post-translational modifications; Protein–protein interaction; Translocation.
. 2021 Sep 6.
doi: 10.1007/s12079-021-00642-2. Online ahead of print.
A pathway map of signaling events triggered upon SARS-CoV infection
K T Shreya Parthasarathi[SUP] #[/SUP][SUP] 1 [/SUP], Nupur S Munjal[SUP] #[/SUP][SUP] 1 [/SUP], Gourav Dey[SUP] 1 [/SUP], Abhishek Kumar[SUP] 1 2 [/SUP], Akhilesh Pandey[SUP] 3 4 5 [/SUP], Lavanya Balakrishnan[SUP] 6 [/SUP], Jyoti Sharma[SUP] 7 8 [/SUP]
Affiliations
- PMID: 34487344
- DOI: 10.1007/s12079-021-00642-2
Abstract
Severe acute respiratory syndrome coronaviruses (SARS-CoVs) caused worldwide epidemics over the past few decades. Extensive studies on various strains of coronaviruses provided a basic understanding of the pathogenesis of the disease. Presently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading a global pandemic with unprecedented challenges. This is the third coronavirus outbreak of this century. A signaling pathway map of signaling events induced by SARS-CoV infection is not yet available. In this study, we present a literature-annotated signaling pathway map of reactions induced by SARS-CoV infected cells. Multiple signaling modules were found to be orchestrated including PI3K-AKT, Ras-MAPK, JAK-STAT, Type 1 IFN and NFκB. The signaling pathway map of SARS-CoV consists of 110 molecules and 101 reactions mediated by SARS-CoV proteins. The pathway reaction data are available in various community standard data exchange formats including Systems Biology Graphical Notation (SBGN). The pathway map is publicly available through the GitHub repository and data in various formats can be freely downloadable.
Keywords: COVID-19; Differential expression; Post-translational modifications; Protein–protein interaction; Translocation.