tetano
Editor, Senior Moderator
J Cell Mol Med
. 2020 Sep 19.
doi: 10.1111/jcmm.15838. Online ahead of print.
STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy
Inbal Shamir[SUP] 1 [/SUP], Mor Abutbul-Amitai[SUP] 1 [/SUP], Haya Abbas-Egbariya[SUP] 1 [/SUP], Metsada Pasmanik-Chor[SUP] 2 [/SUP], Gideon Paret[SUP] 1 3 [/SUP], Yael Nevo-Caspi[SUP] 1 [/SUP]
Affiliations
Abstract
The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3α and STAT3β, and found that while silencing STAT3α causes an increase in ACE2 expression, silencing STAT3β causes the opposite effect. Studying the role of STAT3 in ACE2 expression will shed light on the molecular events that contribute to the progression of the disease and that the different roles of STAT3α and STAT3β in that context must be taken in consideration. Our results place STAT3 in line with additional potential therapeutic targets for treating COVID-19 patients.
Keywords: ACE2; COVID-19; SARS-CoV-2; STAT3 isoforms; STAT3α; STAT3β.
. 2020 Sep 19.
doi: 10.1111/jcmm.15838. Online ahead of print.
STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy
Inbal Shamir[SUP] 1 [/SUP], Mor Abutbul-Amitai[SUP] 1 [/SUP], Haya Abbas-Egbariya[SUP] 1 [/SUP], Metsada Pasmanik-Chor[SUP] 2 [/SUP], Gideon Paret[SUP] 1 3 [/SUP], Yael Nevo-Caspi[SUP] 1 [/SUP]
Affiliations
- PMID: 32949179
- DOI: 10.1111/jcmm.15838
Abstract
The SARS-coronavirus 2 is the aetiologic agent COVID-19. ACE2 has been identified as a cell entry receptor for the virus. Therefore, trying to understand how the gene is controlled has become a major goal. We silenced the expression of STAT3α and STAT3β, and found that while silencing STAT3α causes an increase in ACE2 expression, silencing STAT3β causes the opposite effect. Studying the role of STAT3 in ACE2 expression will shed light on the molecular events that contribute to the progression of the disease and that the different roles of STAT3α and STAT3β in that context must be taken in consideration. Our results place STAT3 in line with additional potential therapeutic targets for treating COVID-19 patients.
Keywords: ACE2; COVID-19; SARS-CoV-2; STAT3 isoforms; STAT3α; STAT3β.