tetano
Editor, Senior Moderator
J Clin Lab Anal
. 2022 Feb 20;e24308.
doi: 10.1002/jcla.24308. Online ahead of print.
COVID-19 in HIV-positive patients: A systematic review of case reports and case series
Mohsen Heidary[SUP] 1 2 [/SUP], Arezoo Asadi[SUP] 3 [/SUP], Negar Noorbakhsh[SUP] 4 [/SUP], Shirin Dashtbin[SUP] 3 [/SUP], Parisa Asadollahi[SUP] 5 [/SUP], Atieh Dranbandi[SUP] 3 [/SUP], Tahereh Navidifar[SUP] 6 [/SUP], Roya Ghanavati[SUP] 4 [/SUP]
Affiliations
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) and acquired immune deficiency syndrome (AIDS) are two viral diseases for which there are currently no definitive treatments. Nowadays, because of the health system's focus on the COVID-19 epidemic, the control of human immunodeficiency virus (HIV) has received less attention. In this review, we will discuss the characteristics of COVID-19 in HIV-positive patients.
Material and methods: Using the PRISMA guideline, the databases of Scopus, PubMed, and Web of Science were searched systematically from January 1, 2019 to February 24, 2021. The following keywords were used: "Human Immunodeficiency Virus," "acquired immune deficiency syndrome," "HIV," "AIDS," "COVID-19," "severe acute respiratory syndrome coronavirus 2," "novel coronavirus," "SARS-CoV-2," "nCoV disease," "SARS2," and "2019-nCoV disease."
Results: Twenty-one percent of studies were conducted in the USA (n = 13), 16% in China (n = 10), and 13% in Italy (n = 8), respectively. The majority of the patients were men (74.3%). Tenofovir disoproxil fumarate was used in 47.4% of patients, emtricitabine in 58.4%, and lamivudine in 34.8% to treat HIV. Symptoms of HIV patients with COVID-19 included coughing (81.3%), fever (62.8%), and dyspnea (60%). Hydroxychloroquine (39.34%) and azithromycin (36.58%) were the common treatment options for COVID-19. The total death rate in HIV-positive patients with COVID-19 was about 9%.
Conclusion: In the current systematic review, we demonstrated that HIV-positive patients co-infected with COVID-19 have high comorbidity of hypertension and diabetes mellitus. HIV/COVID-19 co-infection might have negatively influenced the HIV treatment and diagnosis, which indicates the need to regularly screen HIV patients in the COVID-19 pandemic.
Keywords: COVID-19; HIV; co-infection; review.
. 2022 Feb 20;e24308.
doi: 10.1002/jcla.24308. Online ahead of print.
COVID-19 in HIV-positive patients: A systematic review of case reports and case series
Mohsen Heidary[SUP] 1 2 [/SUP], Arezoo Asadi[SUP] 3 [/SUP], Negar Noorbakhsh[SUP] 4 [/SUP], Shirin Dashtbin[SUP] 3 [/SUP], Parisa Asadollahi[SUP] 5 [/SUP], Atieh Dranbandi[SUP] 3 [/SUP], Tahereh Navidifar[SUP] 6 [/SUP], Roya Ghanavati[SUP] 4 [/SUP]
Affiliations
- PMID: 35187723
- DOI: 10.1002/jcla.24308
Abstract
Introduction: Coronavirus disease 2019 (COVID-19) and acquired immune deficiency syndrome (AIDS) are two viral diseases for which there are currently no definitive treatments. Nowadays, because of the health system's focus on the COVID-19 epidemic, the control of human immunodeficiency virus (HIV) has received less attention. In this review, we will discuss the characteristics of COVID-19 in HIV-positive patients.
Material and methods: Using the PRISMA guideline, the databases of Scopus, PubMed, and Web of Science were searched systematically from January 1, 2019 to February 24, 2021. The following keywords were used: "Human Immunodeficiency Virus," "acquired immune deficiency syndrome," "HIV," "AIDS," "COVID-19," "severe acute respiratory syndrome coronavirus 2," "novel coronavirus," "SARS-CoV-2," "nCoV disease," "SARS2," and "2019-nCoV disease."
Results: Twenty-one percent of studies were conducted in the USA (n = 13), 16% in China (n = 10), and 13% in Italy (n = 8), respectively. The majority of the patients were men (74.3%). Tenofovir disoproxil fumarate was used in 47.4% of patients, emtricitabine in 58.4%, and lamivudine in 34.8% to treat HIV. Symptoms of HIV patients with COVID-19 included coughing (81.3%), fever (62.8%), and dyspnea (60%). Hydroxychloroquine (39.34%) and azithromycin (36.58%) were the common treatment options for COVID-19. The total death rate in HIV-positive patients with COVID-19 was about 9%.
Conclusion: In the current systematic review, we demonstrated that HIV-positive patients co-infected with COVID-19 have high comorbidity of hypertension and diabetes mellitus. HIV/COVID-19 co-infection might have negatively influenced the HIV treatment and diagnosis, which indicates the need to regularly screen HIV patients in the COVID-19 pandemic.
Keywords: COVID-19; HIV; co-infection; review.