tetano
Editor, Senior Moderator
J Clin Lab Anal
. 2021 Feb 12;e23685.
doi: 10.1002/jcla.23685. Online ahead of print.
Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings
Ding-Feng Lv[SUP] 1 2 3 [/SUP], Qi-Ming Ying[SUP] 2 [/SUP], Yi-Wen He[SUP] 2 [/SUP], Jun Liang[SUP] 2 [/SUP], Ji-Hong Zhang[SUP] 4 [/SUP], Bei-Bei Lu[SUP] 5 [/SUP], Guo-Qing Qian[SUP] 6 [/SUP], Jin-Guo Chu[SUP] 7 [/SUP], Xing-Bei Weng[SUP] 2 [/SUP], Xue-Qin Chen[SUP] 8 [/SUP], Qi-Tian Mu[SUP] 9 [/SUP]
Affiliations
Abstract
Background: Pneumonia caused by the 2019 novel Coronavirus (COVID-2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis.
Methods: We retrospectively retrieved data for laboratory-confirmed patients admitted with COVID-19-induced or influenza A-induced pneumonia from electronic medical records in Ningbo First Hospital, China. We recorded patients' epidemiological and clinical features, as well as radiologic and laboratory findings.
Results: The median age of influenza A cohort was higher and it exhibited higher temperature and higher proportion of pleural effusion. COVID-19 cohort exhibited higher proportions of fatigue, diarrhea and ground-glass opacity and higher levels of lymphocyte percentage, absolute lymphocyte count, red-cell count, hemoglobin and albumin and presented lower levels of monocytes, c-reactive protein, aspartate aminotransferase, alkaline phosphatase, serum creatinine. Multivariate logistic regression analyses showed that fatigue, ground-glass opacity, and higher level of albumin were independent risk factors for COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count were independent risk factors for influenza A pneumonia.
Conclusions: In terms of COVID-19 pneumonia and influenza A pneumonia, fatigue, ground-glass opacity, and higher level of albumin tend to be helpful for diagnosis of COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count tend to be helpful for the diagnosis of influenza A pneumonia.
Keywords: COVID-19; clinical characteristics; differential diagnosis; influenza A; pneumonia.
. 2021 Feb 12;e23685.
doi: 10.1002/jcla.23685. Online ahead of print.
Differential diagnosis of coronavirus disease 2019 pneumonia or influenza A pneumonia by clinical characteristics and laboratory findings
Ding-Feng Lv[SUP] 1 2 3 [/SUP], Qi-Ming Ying[SUP] 2 [/SUP], Yi-Wen He[SUP] 2 [/SUP], Jun Liang[SUP] 2 [/SUP], Ji-Hong Zhang[SUP] 4 [/SUP], Bei-Bei Lu[SUP] 5 [/SUP], Guo-Qing Qian[SUP] 6 [/SUP], Jin-Guo Chu[SUP] 7 [/SUP], Xing-Bei Weng[SUP] 2 [/SUP], Xue-Qin Chen[SUP] 8 [/SUP], Qi-Tian Mu[SUP] 9 [/SUP]
Affiliations
- PMID: 33576536
- DOI: 10.1002/jcla.23685
Abstract
Background: Pneumonia caused by the 2019 novel Coronavirus (COVID-2019) shares overlapping signs and symptoms, laboratory findings, imaging features with influenza A pneumonia. We aimed to identify their clinical characteristics to help early diagnosis.
Methods: We retrospectively retrieved data for laboratory-confirmed patients admitted with COVID-19-induced or influenza A-induced pneumonia from electronic medical records in Ningbo First Hospital, China. We recorded patients' epidemiological and clinical features, as well as radiologic and laboratory findings.
Results: The median age of influenza A cohort was higher and it exhibited higher temperature and higher proportion of pleural effusion. COVID-19 cohort exhibited higher proportions of fatigue, diarrhea and ground-glass opacity and higher levels of lymphocyte percentage, absolute lymphocyte count, red-cell count, hemoglobin and albumin and presented lower levels of monocytes, c-reactive protein, aspartate aminotransferase, alkaline phosphatase, serum creatinine. Multivariate logistic regression analyses showed that fatigue, ground-glass opacity, and higher level of albumin were independent risk factors for COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count were independent risk factors for influenza A pneumonia.
Conclusions: In terms of COVID-19 pneumonia and influenza A pneumonia, fatigue, ground-glass opacity, and higher level of albumin tend to be helpful for diagnosis of COVID-19 pneumonia, while older age, higher temperature, and higher level of monocyte count tend to be helpful for the diagnosis of influenza A pneumonia.
Keywords: COVID-19; clinical characteristics; differential diagnosis; influenza A; pneumonia.